Longitudinal Cerebral Blood Flow Changes in Normal Aging and the Alzheimer's Disease Continuum Identified by Arterial Spin Labeling MRI.
Longitudinal Cerebral Blood Flow Changes in Normal Aging and the Alzheimer's Disease Continuum Identified by Arterial Spin Labeling MRI.
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DOI：
10.3233/jad-210116
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
中科院分区：
文献类型：
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作者：
Camargo A;Wang Z;Alzheimer’s Disease Neuroimaging Initiative
横断面研究表明，阿尔茨海默病（AD）的脑血流量（CBF）较低，但AD的纵向CBF变化仍然未知。为揭示正常对照组（NC）和AD连续体的纵向CBF变化，应用动脉自旋标记灌注MRI（ASL MRI）对140名AD患者进行了2次ASL纵向扫描，测量时间间隔为2.22 ± 1.43年。在基线扫描时，该队列包含41名NC，74名轻度认知障碍患者（MCI）和25名AD患者。随访时21例NC转为MCI，17例MCI转为AD。在每个体素和元ROI中分别使用配对t检验评估非转换器和转换器的纵向CBF变化。年龄和性别作为协变量。在所有受试者中均观察到CBF降低。稳定的NC（n=20）显示海马和楔前叶中的CBF减少。稳定MCI患者（n=57）在海马、中颞叶、腹侧纹状体、前额叶皮质和小脑中表现出空间上更广泛的CBF减少模式。NC-MCI转换器显示海马和小脑CBF减少，尾状核CBF增加。MCI-AD转换器显示海马和前额叶皮质CBF减少。CBF变化与纵向神经认知功能改变无关。正常老化和AD连续表现出共同的纵向CBF减少海马独立的疾病及其转换。MCI患者的疾病转换独立的纵向CBF降低逐渐增加。
Cross-sectional studies have shown lower cerebral blood flow (CBF) in Alzheimer’s disease (AD) but longitudinal CBF changes in AD are still unknown. To reveal the longitudinal CBF changes in normal control (NC) and the AD continuum using Arterial Spin Labeling perfusion MRI (ASL MRI) CBF was calculated from two longitudinal ASL scans acquired in 2.22 ± 1.43 years apart from 140 subjects from the Alzheimeŕs Disease Neuroimaging Initiative (ADNI). At the baseline scan, the cohort contained 41 NC, 74 mild cognitive impairment patients (MCI), and 25 AD patients. 21 NC converted into MCI and 17 MCI converted into AD at the follow-up. Longitudinal CBF changes were assessed using paired-t test for non-converters and converters separately at each voxel and in the meta-ROI. Age and sex were used as covariates. CBF reductions were observed in all subjects. Stable NC (n=20) showed CBF reduction in the hippocampus and precuneus. Stable MCI patients (n=57) showed spatially more extended CBF reduction patterns in hippocampus, middle temporal lobe, ventral striatum, prefrontal cortex, and cerebellum. NC-MCI converters showed CBF reduction in hippocampus and cerebellum and CBF increase in caudate. MCI-AD converters showed CBF reduction in hippocampus and prefrontal cortex. CBF changes were not related with longitudinal neurocognitive changes. Normal aging and AD continuum showed common longitudinal CBF reductions in hippocampus independent of disease and its conversion. Disease conversion independent longitudinal CBF reductions escalated in the MCI.