Widespread parallel evolution in sticklebacks by repeated fixation of ectodysplasin alleles
Widespread parallel evolution in sticklebacks by repeated fixation of ectodysplasin alleles
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DOI：
10.1126/science.1107239
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发表时间：
2005-03-25
期刊：
影响因子：
56.9
通讯作者：
Kingsley, DM
中科院分区：
文献类型：
--
作者：
Colosimo, PF;Hosemann, KE;Kingsley, DM
主要的表型变化在自然界中通过分子机制平行进化，这些机制在很大程度上是未知的。在这里，我们使用位置克隆方法来确定主要的染色体位点控制装甲板图案在野生threespine刺鱼。定位、测序和转基因研究表明，外胚层发育不良（EDA）信号通路在自然种群的进化变化中起着关键作用，并且是平行进化。在世界上大多数淡水地区，棘鱼低板表型的重复选择是通过重复选择来自祖先低板单倍型的Eda等位基因而发生的，该单倍型首次出现于200多万年前。该分支的拖板等位基因的成员存在于海洋鱼类中的两个频率，这表明，常设的遗传变异可以提供一个分子基础，快速，平行进化的戏剧性的表型变化的性质。
Major phenotypic changes evolve in parallel in nature by molecular mechanisms that are largely unknown. Here, we use positional cloning methods to identify the major chromosome locus controlling armor plate patterning in wild threespine sticklebacks. Mapping, sequencing, and transgenic studies show that the Ectodysplasin (EDA) signaling pathway plays a key role in evolutionary change in natural populations and that parallel evolution. of stickleback low-plated phenotypes at most freshwater locations around the world has occurred by repeated selection of Eda alleles derived from an ancestral low-plated haplotype that first appeared more than two million years ago. Members of this clade of tow-plated alleles are present at tow frequencies in marine fish, which suggests that standing genetic variation can provide a molecular basis for rapid, parallel evolution of dramatic phenotypic change in nature.