Connective tissue growth factor: a novel player in tissue reorganization after brain injury?
Connective tissue growth factor: a novel player in tissue reorganization after brain injury?
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DOI：
10.1046/j.1460-9568.2000.00930.x
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发表时间：
2000-01-01
影响因子：
3.4
通讯作者：
Werner, S
中科院分区：
文献类型：
--
作者：
Hertel, M;Tretter, Y;Werner, S
最近的研究表明结缔组织生长因子（CTGF）在皮肤修复过程中以及在各种类型的纤维化疾病中的作用。然而，这种分子在中枢神经系统（CNS）修复中的功能尚未得到证实。在这项研究中，我们分析了时间和空间的表达模式CTGF后，单侧海人酸损伤小鼠海马CA3区。我们发现CTGF mRNA和蛋白质表达的强烈诱导损伤海马的神经元和胶质细胞。有趣的是，这种有丝分裂原的表达增加伴随着细胞外基质分子纤连蛋白水平的升高，纤连蛋白是CTGF作用的已知靶点。因此，我们的数据表明CTGF在海马损伤后重建中的新功能，在那里它可能参与胶质瘢痕形成。
Recent studies have suggested a role of connective tissue growth factor (CTGF) in repair processes of the skin as well as in various types of fibrotic disease. However, a function of this molecule in central nervous system (CNS) repair has not been demonstrated yet. In this study we analysed the temporal and spatial expression pattern of CTGF after unilateral kainic acid lesions of the hippocampal CA3 region in mice. We found a strong induction of CTGF mRNA and protein expression in neurons and glial cells of the lesioned hippocampus. Interestingly, increased expression of this mitogen was accompanied by elevated levels of the extracellular matrix molecule fibronectin, which is a known target of CTGF action. Therefore, our data indicate a novel function of CTGF in postlesional restructuring of the hippocampus, where it possibly participates in glial scar formation.