SASBDB: Towards automatically curated and validated repository for biological scattering data
SASBDB: Towards automatically curated and validated repository for biological scattering data
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DOI：
10.1002/pro.3731
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发表时间：
2019-10-11
期刊：
影响因子：
8
通讯作者：
Svergun, Dmitri I.
中科院分区：
文献类型：
--
作者：
Kikhney, Alexey G.;Borges, Clemente R.;Svergun, Dmitri I.
X射线和中子的小角散射（SAS）是研究纳米结构特性，特别是溶液中生物大分子的基本工具。在结构生物学中，SAS最近从专业化转变为通用技术，导致报告结构模型的出版物数量急剧增加。由于记录和发布的数据量不断增加，迫切需要一个包括原始数据和模型的全球SAS存储库。针对这一点，2014年设计了一个小角度散射生物数据库（SASBDB），可供公众访问。SASBDB是一个全面的，免费的和可搜索的SAS实验数据和模型存储库，与相关的实验条件，样品细节和仪器特性一起存放。SASBDB正在迅速发展，目前拥有1，000多个条目，包含1，600多个模型。我们在此描述SASBDB的整体组织和程序，在提交过程中最关注用户相关信息。进一步发展的前景，特别是与OneDep系统的蛋白质数据库，也扩大了SASBDB，包括新类型的数据/模型进行了讨论。
Small-angle scattering (SAS) of X-rays and neutrons is a fundamental tool to study the nanostructural properties, and in particular, biological macromolecules in solution. In structural biology, SAS recently transformed from a specialization into a general technique leading to a dramatic increase in the number of publications reporting structural models. The growing amount of data recorded and published has led to an urgent need for a global SAS repository that includes both primary data and models. In response to this, a small-angle scattering biological data bank (SASBDB) was designed in 2014 and is available for public access at . SASBDB is a comprehensive, free and searchable repository of SAS experimental data and models deposited together with the relevant experimental conditions, sample details and instrument characteristics. SASBDB is rapidly growing, and presently has over 1,000 entries containing more than 1,600 models. We describe here the overall organization and procedures of SASBDB paying most attention to user-relevant information during submission. Perspectives of further developments, in particular, with OneDep system of the Protein Data Bank, and also widening of SASBDB including new types of data/models are discussed.