The effects of monoacrylated poly(ethylene glycol) on the properties of poly(ethylene glycol) diacrylate hydrogels used for tissue engineering
The effects of monoacrylated poly(ethylene glycol) on the properties of poly(ethylene glycol) diacrylate hydrogels used for tissue engineering
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DOI：
10.1002/jbm.a.32353
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发表时间：
2010-02-01
影响因子：
4.9
通讯作者：
Marchant, Roger E.
中科院分区：
文献类型：
--
作者：
Beamish, Jeffrey A.;Zhu, Junmin;Marchant, Roger E.
本研究研究了聚乙二醇单丙烯酸酯 (PEGMA) 对聚乙二醇二丙烯酸酯 (PEGDA)-co-PEGMA 水凝胶网络性能的影响。所使用的 PEGMA 材料类似于通常与 PEGDA 共聚用作组织工程支架的配体连接材料。通过光引发自由基聚合将PEGDA（5-20% wt/wt，6 kDa）和PEGMA（0-20% wt/wt，0-43 mM，5 kDa）共聚，并测定所得水凝胶的质量溶胀比和剪切模量。增加 PEGMA 的预聚浓度可将溶胀率降低高达 42 +/- 1.6%，并将剪切模量增加高达 167 +/- 29.3%，这表明 PEGMA 增强了凝胶交联。对每个 PEGDA 的有效交联链数量的分析（独立于溶胀和机械数据计算）表明，随着添加 PEGMA，每个 PEGDA 参与更多的交联。结果表明，与之前报道的相比，PEGMA-co-PEGDA 凝胶可以用更高浓度的 PEGMA 系留配体形成，从而允许形成具有丰富多样性生物功能的支架，而不牺牲凝胶网络的完整性。 (C) 2009 Wiley periodicals, Inc. J Biomed Mater Res 92A: 441-450, 2010
This study investigated the effects of poly(ethylene glycol) monoacrylate (PEGMA) on the properties of poly(ethylene glycol) diacrylate (PEGDA)-co-PEGMA hydrogel networks. The PEGMA materials utilized were similar to ligand-linked materials typically copolymerized with PEGDA for use as tissue engineering scaffolds. PEGDA (5-20% wt/wt, 6 kDa) and PEGMA (0-20% wt/wt, 0-43 mM, 5 kDa) were copolymerized by photo-initiated free radical polymerization and the mass swelling ratio and shear modulus of the resulting hydrogels were determined. Increasing the prepolymerization concentration of PEGMA decreased the swelling ratio by up to 42 +/- 1.6% and increased the shear modulus by up to 167 +/- 29.3%, suggesting that PEGMA enhanced gel cross-linking. Analysis of the effective number of cross-linked chains per PEGDA, calculated independently from swelling and mechanical data, indicated each PEGDA participated in more cross-links as PEGMA was added. The results suggest that PEGMA-co-PEGDA gels can be formed with higher concentrations of PEGMA-tethered ligands than previously reported allowing the formation of scaffolds with a rich diversity of biological functionalities without sacrificing the integrity of the gel network. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 92A: 441-450, 2010