Association of frequent consumption of fatty fish with prostate cancer risk is modified by COX-2 polymorphism
Association of frequent consumption of fatty fish with prostate cancer risk is modified by COX-2 polymorphism
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DOI：
10.1002/ijc.22319
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发表时间：
2007-01-15
影响因子：
6.4
通讯作者：
Balter, Katarina Augustsson
中科院分区：
文献类型：
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作者：
Hedelin, Maria;Chang, Ellen T.;Balter, Katarina Augustsson
从鱼类中摄取海洋脂肪酸可以预防前列腺癌的发展。我们研究了这种关联以及它是否被环氧合酶（考克斯）-2（脂肪酸代谢和炎症中的关键酶）的遗传变异所修饰。我们评估了瑞典1,499例前列腺癌病例和1,130例对照人群的鱼类饮食摄入量。在1，378例病例和782例对照的血液样本中发现了5个单核苷酸多态性（SNP）并进行了基因分型。采用多因素Logistic回归分析，计算OR值和95%可信区间（CI）。鱼类摄入量和考克斯-2单核苷酸多态性之间的乘法和加法的相互作用对前列腺癌的风险进行了评估。每周吃一次或多次脂肪鱼（例如鲑鱼类鱼）与从不吃相比，与前列腺癌风险降低相关（OR：0.57，95% CI：0.43-0.76）。比较海洋脂肪酸摄入量最高和最低四分位数的OR为0.70（95%CI：0.51-0.97）。我们发现鲑鱼类鱼类摄入量与考克斯-2基因中的SNP（rs 5275：+6365 T/C）之间存在显著的相互作用（p < 0.001），但与其他4种SNP之间没有相互作用。我们发现，在变异等位基因携带者中，鲑鱼类鱼类摄入量的增加与鲑鱼类鱼类摄入量的增加有很强的负相关性（每周一次或更多次与从不摄入的OR = 0.28，95% CI：0.18-0.45; p（趋势）< 0.01），但在更常见等位基因携带者中没有相关性。经常食用富含脂肪的鱼类和海洋脂肪酸似乎可以降低患前列腺癌的风险，而这种关联是通过考克斯-2基因的遗传变异来改变的。(c)2006 Wiley-Liss，Inc.
Dietary intake of marine fatty acids from fish may protect against prostate cancer development. We studied this association and whether it is modified by genetic variation in cyclooxygenase (COX)-2, a key enzyme in fatty acid metabolism and inflammation. We assessed dietary intake of fish among 1,499 incident prostate cancer cases and 1,130 population controls in Sweden. Five single nucleotide polymorphisms (SNPs) were identified and genotyped in available blood samples for 1,378 cases and 782 controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by multivariate logistic regression. Multiplicative and additive interactions between fish intake and COX-2 SNPs on prostate cancer risk were evaluated. Eating fatty fish (e.g. salmon-type fish) once or more per week, compared to never, was associated with reduced risk of prostate cancer (OR: 0.57, 95% CI: 0.43-0.76). The OR comparing the highest to the lowest quartile of marine fatty acids intake was 0.70 (95% CI: 0.51-0.97). We found a significant interaction (p < 0.001) between salmon-type fish intake and a SNP in the COX-2 gene (rs5275: +6365 T/C), but not with the 4 other SNPs examined. We found strong inverse associations with increasing intake of salmon-type fish among carriers of the variant allele (OR for once per week or more vs. never = 0.28, 95% CI: 0.18-0.45; p(trend) < 0.01), but no association among carriers of the more common allele. Frequent consumption of fatty fish and marine fatty acids appears to reduce the risk of prostate cancer, and this association is modified by genetic variation in the COX-2 gene. (c) 2006 Wiley-Liss, Inc.