Prenatal and postnatal development after transitory gestational zinc deficiency in rats.
Prenatal and postnatal development after transitory gestational zinc deficiency in rats.
复制标题
大鼠短暂妊娠缺锌后的产前和产后发育。
DOI：
10.1093/jn/103.5.649
复制
发表时间：
1973
期刊：
影响因子：
--
通讯作者：
P. B. Mutch
中科院分区：
文献类型：
--
作者：
Lucille S. Hurley;P. B. Mutch
研究了妊娠期母体短暂缺锌对大鼠出生后生长、存活和锌营养状况的影响。雌性大鼠在妊娠第6天至第14天之间喂食缺锌饮食，在此期间血浆锌水平显着降低，在补充锌后迅速恢复正常。他们生下的后代体重减轻，先天畸形的发生率很高。许多年轻的死产，断奶的存活率很低，尽管幸存者的产后生长是正常的。在同一时期，限制食物摄入的雌性动物未发生这些变化。母鼠分娩后血浆锌明显升高，乳汁中锌含量约为血浆锌含量的10倍。新生大鼠的血浆锌水平是成年大鼠的四倍。母鼠或仔鼠出生后乳汁和血浆中锌的浓度不受孕期饮食处理的影响，因此出生后锌营养状况正常。因此，在怀孕期间短时间内喂养缺锌饮食的雌性所生下的幼崽存活率低不能归因于产后锌摄入不足。先天性畸形可能是一个因素;由于出生时身体虚弱而无法正常发育也可能涉及。J. Nutr. 103：649-656，1973.
The consequences of transitory maternal zinc deficiency during gestation on postnatal growth, survival, and zinc status of rats were investigated. Female rats fed a zinc-deficient diet between days 6 and 14 of pregnancy had markedly lowered plasma zinc levels during this period which quickly became normal after zinc supple mentation. They gave birth to offspring reduced in weight and with a high incidence of congenital malformations. Many of the young were stillborn, and survival to weaning was poor, although postnatal growth of survivors was normal. None of these changes occurred in females restricted in food intake during the same period. After parturition the plasma zinc of the female rat increased markedly, and the milk contained about 10 times as much zinc as the blood plasma. Neonatal rats were found to have plasma zinc levels four times greater than those of adult rats. Concentrations of zinc in milk and in plasma of mothers or young after birth were unaffected by the dietary treatment during pregnancy so that postnatal zinc nutriture was normal. The poor survival of young born to females fed a zinc-deficient diet for a short period during pregnancy cannot therefore be attributed to inadequate postnatal zinc intake. Congenital abnormalities may be a factor; failure to suckle due to weakness at birth may also be involved. J. Nutr. 103: 649-656, 1973.