Fabrication of Paper-based Microfluidic Devices Using a Laser Beam Scanning Technique
Fabrication of Paper-based Microfluidic Devices Using a Laser Beam Scanning Technique
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DOI：
10.2116/analsci.20p196
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发表时间：
2020-10-01
影响因子：
1.6
通讯作者：
Ishizaka, Shoji
中科院分区：
文献类型：
--
作者：
Hiep, Dang Huy;Tanaka, Yuta;Ishizaka, Shoji
本文介绍了一种利用激光束扫描技术制备纸基微流控器件的新方法。用十八烷基三氯硅烷（OTS）处理纤维素色谱纸，使其完全疏水。将光酸发生器（CPI-410S）浸泡在纸上，用405 nm激光束照射，诱导产酸反应。由于纤维素与OTS之间的硅醚键被水解反应破坏，光照射区变为亲水区。利用Galvo反射镜系统扫描激光束，成功地在纸上形成了分辨率为50 μ m的任意形状的亲水图案。据我们所知，这是第一篇利用光诱导产酸工艺结合激光束扫描技术在ots处理纸上制备亲水性通道的报道。用该方法制作的纸制装置进行了亚硝酸盐定量实验。
This paper describes a novel method for fabricating paper-based microfluidic devices using a laser beam scanning technique. Cellulose chromatography papers were treated with octadecyltrichlorosilane (OTS) to make them entirely hydrophobic. A photoacid generator (CPI-410S) was soaked into the paper, and irradiated with a 405-nm laser beam to induce acid generating reactions. Since the silyl ether bond between cellulose and OTS was cleaved by the hydrolysis reaction, the photo-irradiated area changed to hydrophilic. By scanning the laser beam using a Galvo mirror system, arbitrary shaped hydrophilic patterns were successfully created on the paper in 50 mu m resolution. To the best of our knowledge, this is the first report on the fabrication of hydrophilic channels on the OTS-treated paper using photo-induced acid generation processes coupled with the laser beam scanning technique. Quantification of nitrite was demonstrated with the paper device made by this method.