A comparative study of two different methods for the detection of latent tuberculosis in HIV-positive individuals in Chile
A comparative study of two different methods for the detection of latent tuberculosis in HIV-positive individuals in Chile
复制标题
DOI：
10.1016/j.ijid.2008.03.005
复制
发表时间：
2008-11-01
影响因子：
8.4
通讯作者：
Garcia, Patricia
中科院分区：
文献类型：
--
作者：
Balcells, Maria Elvira;Perez, Carlos M.;Garcia, Patricia
目的：比较两种检测方法在智利HIV阳性人群中诊断潜伏性结核病（TB）感染的性能，以便更好地识别可能受益于TB趋化性的受试者。设计：这是一项在圣地亚哥的三家HIV门诊诊所就诊的个体中进行的横断面研究，用2-TU纯化的蛋白衍生物QuantiFERON“-TB Gold "管内”（QFT-G）进行测试，结果：共有116名受试者参加了这项研究，平均CD 4计数为393个细胞/μ l（范围100-977）。结核菌素皮肤试验（TST; 5 mm临界值）和QFF-G结果分别在10.9%和14.8%的个体中呈阳性，两种试验之间具有中度一致性（kappa = 0.59）。已知TB暴露史（比值比（OR）3.46，95%置信区间（CI）1.02-11.22）和既往TB（OR 4.31，95% CI 1.13-15.5）与阳性QFT-G结果相关。仅既往TB与阳性TST结果显著相关（OR 6.63，95%CI 1.6226.3）。TST < 5 mm者QFT-G试验阳性率为8.2%。这些人有一个较低的平均CD 4细胞计数比检测阳性的两个测试（328个细胞/亩和560个细胞/亩，分别为，p=0.03）。结论：在这个人口的HIV感染的个人，QFT-G和TST表现出一个可接受的水平的协议，虽然QFT-G出现更先进的免疫抑制的影响较小。(C)2008年国际传染病学会。由爱思唯尔有限公司出版。保留所有权利。
Objective: To compare the performance of two tests for diagnosing latent tuberculosis (TB) infection in the HIV-positive population in Chile, in order to better identify the subjects who might benefit from TB chemoprophytaxis.Design: This was a cross-sectional study among individuals attending three HIV outpatient clinics in Santiago, tested with a 2-TU purified protein derivative, QuantiFERON "-TB Gold 'in-tube' (QFT-G), and a chest X-ray.Results: A total of 116 subjects were enrolled in the study, having a mean CD4 count of 393 celts/mu l (range 100-977). The tuberculin skin text (TST; 5 mm cutoff) and QFF-G results were positive in 10.9% and 14.8% of the individuals, respectively, with moderate agreement between both tests (kappa = 0.59). A history of both known TB exposure (odds ratio (OR) 3.46, 95% confidence interval (CI) 1.02-11.22) and past TB (OR 4.31, 95% CI 1.13-15.5) were associated with a positive QFT-G result. Only past TB was significantly associated with a positive TST result (OR 6.63, 95% CI 1.6226.3). Among the subjects with TST < 5 mm, 8.2% were positive by QFT-G test. These individuals had a lower mean CD4 cell count than those detected positive by both tests (328 cells/mu l and 560 cells/mu l, respectively, p=0.03).Conclusions: In this population of HIV-infected individuals, QFT-G and TSTshowed an acceptable level of agreement, although QFT-G appears less affected by more advanced immunosuppression. (C) 2008 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.