Effects of phytate and pyrophosphate on brushite and hydroxyapatite crystallization -: Comparison with the action of other polyphosphates
Effects of phytate and pyrophosphate on brushite and hydroxyapatite crystallization -: Comparison with the action of other polyphosphates
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DOI：
10.1007/s002400050152
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发表时间：
2000-04-01
影响因子：
--
通讯作者：
Costa-Bauzá, A
中科院分区：
文献类型：
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作者：
Grases, F;Ramis, M;Costa-Bauzá, A
比较研究了植酸盐、焦磷酸盐和其他聚磷酸盐对羟基磷灰石和刷石结晶的影响。最常见的钙磷酸盐参与草酸钙尿石症。通过动力学-浊度测量，研究了合成尿液中刷石和羟基磷灰石晶体的形成，以评估其对不溶性盐结晶的抑制作用。防止刷石结晶的有效性顺序为植酸盐；聚磷酸盐；EDTPO>；乙二磷酸；焦磷酸盐；三磷酸；三磷酸甲酯；而防止羟基磷灰石结晶的有效性顺序为EDTPO>；乙二磷酸=焦磷酸盐；三磷酸盐；乙二磷酸；聚磷酸盐；植酸盐。尿液中的天然抑制剂植酸盐最有效地阻止了刷石的析出(1.21.10(-5)M在至少1小时内阻止了结晶)，焦磷酸盐是最有效地阻止羟基磷灰石析出的天然抑制剂(2.87.10(-6)M在至少1小时内阻止了结晶)。这表明，这些物质的低排泄量会造成肾结石的风险。
This is a comparative study of the effects of phytate and pyrophosphate and other polyphosphates on the crystallization of hydroxyapatite and brushite. the most frequent calcium phosphates involved in calcium oxalate urolithiasis. Brushite and hydroxyapatite crystal Formation was studied in synthetic urine, through kinetic-turbidimetric measurements that allowed evaluation of the inhibitory effects on crystallization of insoluble salts. The effectiveness in preventing brushite crystallization decreases in the sequence phytate > polyphosphate > EDTPO > etidronate > pyrophosphate > triphosphate > medronate, whereas the order of effectiveness in preventing hydroxyapatite crystallization was EDTPO > etidronate = pyrophosphate > triphosphate > medronate > polyphosphate > phytate. Phytate, a natural inhibitor in urine, most effectively blocked brushite precipitation (1.21.10(-5) M prevented crystallization during time periods of at least 1 h), and pyrophosphate was the natural inhibitor that most effectively blocked hydroxyapatite precipitation (2.87.10(-6) M prevented crystallization during time periods of at least 1 h). This demonstrates that low excretion of these substances would pose a risk of renal lithiasis.