Nanoparticle Uptake: The Phagocyte Problem.
Nanoparticle Uptake: The Phagocyte Problem.
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DOI：
10.1016/j.nantod.2015.06.006
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发表时间：
2015-08
期刊：
影响因子：
17.4
通讯作者：
Ghandehari H
中科院分区：
文献类型：
--
作者：
Gustafson HH;Holt-Casper D;Grainger DW;Ghandehari H
吞噬细胞是决定宿主暴露于纳米材料的重要方面的关键细胞参与者，启动清除，生物分布以及宿主耐受性和不良纳米毒性之间的微妙平衡。特别是巨噬细胞被认为是处理纳米颗粒、介导宿主炎症和免疫生物学反应的第一和主要细胞类型之一。这些过程在纳米材料存在的组织中无处不在，包括宿主专用过滤器官（即肝、肾、脾和肺）中的宿主单核吞噬系统（MPS）。因此，要了解纳米材料暴露的风险，关键是要了解纳米材料如何在不同类型的宿主巨噬细胞中被识别、内化、运输和分布，以及纳米材料暴露导致的细胞基反应如何在体内进一步促进宿主的炎症反应。这篇综述的重点是描述巨噬细胞引发的下游标志性免疫和炎症过程，这些过程是由吞噬细胞暴露于纳米材料和内化引起的。
Phagocytes are key cellular participants determining important aspects of host exposure to nanomaterials, initiating clearance, biodistribution and the tenuous balance between host tolerance and adverse nanotoxicity. Macrophages in particular are believed to be among the first and primary cell types that process nanoparticles, mediating host inflammatory and immunological biological responses. These processes occur ubiquitously throughout tissues where nanomaterials are present, including the host mononuclear phagocytic system (MPS) residents in dedicated host filtration organs (i.e., liver, kidney spleen, and lung). Thus, to understand nanomaterials exposure risks it is critical to understand how nanomaterials are recognized, internalized, trafficked and distributed within diverse types of host macrophages and how possible cell-based reactions resulting from nanomaterial exposures further inflammatory host responses in vivo. This review focuses on describing macrophage-based initiation of downstream hallmark immunological and inflammatory processes resulting from phagocyte exposure to and internalization of nanomaterials.