Formation and maintenance of the organizer among the vertebrates.
Formation and maintenance of the organizer among the vertebrates.
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DOI：
10.1387/ijdb.11291844
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Katherine Joubin;Claudio D. Stern
中科院分区：
文献类型：
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作者：
Katherine Joubin;Claudio D. Stern
组织者在囊胚发育阶段建立，在两栖动物中被称为Nieuwkoop中心的细胞特殊区域的影响下，Vg1/激活素样信号与wnt通路的活性重叠。尽管它们的早期发育模式有所不同，但在其他脊椎动物中也可以发现类似的区域。人们普遍认为，一旦在这个早期阶段将组织者属性分配给细胞，它就被固定了，因此在原肠胚阶段，没有新的细胞获得组织者属性。然而，当组织者被切除时，它可以在原肠胚形成过程中再生一段有限的时间，这一过程受到胚胎中各个区域发出的积极和消极信号的调节。在这里，我们比较了在不同脊椎动物类别中最初在囊胚中建立组织者和在原肠胚形成过程中维持组织者的机制，并认为类似的分子机制可能涉及这两个过程。我们还认为，这些机制是必要的，以确保组织者属性的适当位置在原肠中，细胞不断移动。
The organizer is established at the blastula stage of development, under the influence of a special region of cells known as the Nieuwkoop center in amphibians, where Vg1/activin-like signals overlap with activity of the Wnt-pathway. Despite differences in their mode of early development, a similar region can be identified in other vertebrates. It has widely been assumed that once the organizer property is assigned to cells at this early stage, it is fixed so that by the gastrula stage, no new cells acquire organizer properties. However, when the organizer is ablated, it can regenerate for a limited period during gastrulation, a process regulated by both positive and negative signals emanating from various domains in the embryo. Here we compare the mechanisms that initially establish the organiser in the blastula with those that maintain it during gastrulation in different vertebrate classes, and argue that similar molecular mechanisms may be involved in the two processes. We also suggest that these mechanisms are required to ensure the appropriate location of the organizer property in the gastrula, where cells are continuously moving.