Hyperpolarized 129Xe lung MRI in spontaneously breathing mice with respiratory gated fast imaging and its application to pulmonary functional imaging
Hyperpolarized 129Xe lung MRI in spontaneously breathing mice with respiratory gated fast imaging and its application to pulmonary functional imaging
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DOI：
10.1002/nbm.1697
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发表时间：
2011-12-01
影响因子：
2.9
通讯作者：
Fujiwara, Hideaki
中科院分区：
文献类型：
--
作者：
Imai, Hirohiko;Kimura, Atsuomi;Fujiwara, Hideaki
在本研究中，一个平衡的稳态自由旋进脉冲序列结合压缩感知应用于超极化129毫米波肺成像在自主呼吸的小鼠。借助于快速成像技术，所得到的图像的时间分辨率得到显著提高。应用这些方案和呼吸门控技术，成功地获得了129例吸气末和呼气末肺图像。应用这些技术进行肺功能成像，可以同时评价同一动物的局部通气和气体交换。健康小鼠和弹性蛋白酶诱导的肺气肿小鼠模型之间的比较研究显示，弹性蛋白酶处理的小鼠中存在异常通气和气体交换。版权所有（C）2011约翰威利父子有限公司
In the present study, a balanced steady-state free precession pulse sequence combined with compressed sensing was applied to hyperpolarized 129Xe lung imaging in spontaneously breathing mice. With the aid of fast imaging techniques, the temporal resolution was markedly improved in the resulting images. Using these protocols and respiratory gating, 129Xe lung images in end-inspiratory and end-expiratory phases were obtained successfully. The application of these techniques for pulmonary functional imaging made it possible to simultaneously evaluate regional ventilation and gas exchange in the same animal. A comparative study between healthy and elastase-induced mouse models of emphysema showed abnormal ventilation as well as gas exchange in elastase-treated mice. Copyright (C) 2011 John Wiley & Sons, Ltd.