Identification of the neural correlates of cyclothymic temperament using an esthetic judgment for paintings task in fMRI
Identification of the neural correlates of cyclothymic temperament using an esthetic judgment for paintings task in fMRI
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DOI：
10.1016/j.jad.2014.07.037
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发表时间：
2014-12-01
影响因子：
6.6
通讯作者：
Kochiyama, Takanori
中科院分区：
文献类型：
--
作者：
Mizokami, Yoshinori;Terao, Takeshi;Kochiyama, Takanori
背景：众所周知，艺术创造力与回旋胸腺气质之间存在关联，但回旋胸腺气质的神经关联尚未完全确定。最近，我们发现左侧舌回和双侧楔形核可能与具象绘画的审美判断有关，因此我们试图通过测量回旋胸腺气质来研究绘画审美判断过程中的脑活动。方法：使用自动解剖标记技术在左侧舌回和双侧楔形核设置感兴趣区，并用Marsbar工具箱测量感兴趣区的百分比信号变化。通过皮尔逊系数考察了绘画审美判断中感兴趣区的百分比信号变化与回旋胸腺气质得分之间的关系。结果：在绘画审美判断过程中，环胸腺气质分数与左侧舌回的信号变化百分比呈显著负相关，而与双侧楔叶的相关不显著。限制：受试者数量相对较少，任务仅限于鉴赏绘画。结论：本研究结果提示，回旋胸腺气质可能与左侧舌回有关。(C)2014爱思唯尔B.V.保留所有权利。
Background: There is a well-known association between artistic creativity and cyclothymic temperament but the neural correlates of cyclothymic temperament have not yet been fully identified. Recently, we showed that the left lingual gyrus and bilateral cuneus may be associated with esthetic judgment of representational paintings, we therefore sought to investigate brain activity during esthetic judgment of paintings in relation to measures of cyclothymic temperament.Methods: Regions of interest (ROI) were set at the left lingual gyrus and bilateral cuneus using automated anatomical labeling, and percent signal changes of the ROIs were measured by marsbar toolbox. The associations between percent signal changes of the ROIs during esthetic judgments of paintings and cyclothymic temperament scores were investigated by Pearson's coefficient. Moreover, the associations were further analyzed using multiple regression analysis whereby cyclothymic temperament scores were a dependent factor and percent signal changes of the 3 ROIs and the other 4 temperament scores were independent factors.Results: There was a significantly negative association of cyclothymic temperament scores with the percent signal changes of the left lingual gyrus during esthetic judgments of paintings, but not with those of bilateral cuneus. Even after adjustment using multiple regression analysis, this finding remained unchanged.Limitations: The number of subjects was relatively small and the task was limited to appreciation of paintings.Conclusions: The present findings suggest that cyclothymic temperament may be associated with the left lingual gyrus. (C) 2014 Elsevier B.V. All rights reserved.