Time-frequency analysis of spike-wave discharges using a modified wavelet transform
Time-frequency analysis of spike-wave discharges using a modified wavelet transform
复制标题
DOI：
10.1016/j.jneumeth.2005.12.006
复制
发表时间：
2006-06-30
影响因子：
3
通讯作者：
van Luijtelaar, Gilles
中科院分区：
文献类型：
--
作者：
Bosnyakova, Daria;Gabova, Alexandra;van Luijtelaar, Gilles
连续Morlet小波变换用于分析的时频模式的棘波放电（SWD），可以记录在一个遗传性的失神癫痫动物模型（大鼠的WAG/Rij株）。我们开发了一种新的小波变换，允许获得的时间-频率动态的放电过程中的主导节奏。在某些药物给药前和给药后分析SWD。SWD记录的predrug表现出相当均匀的时间-频率动态的优势节奏。放电的开始具有最高频率值（高达15 Hz）的短周期。然后频率降低到7-9 Hz，并且在放电期间在该范围内以0.5-0.7 s的周期发生频率调制。SWD时频动力学的具体变化后，发现精神活性药物，解决不同的大脑介质和调制系统。在低剂量（0.5mg/kg）氟哌啶醇作用下，出现短的多次SWD，其特征是在每次放电结束时频率快速下降至5-6 Hz。1.0 mg/kg或更高剂量氟哌啶醇给药后，长时程SWD的主频率不稳定，出现两个周期，氨己烯酸给药后长时程SWD的放电频率稳定。氯胺酮给药后的EEG表现出明显的5 s准周期性。围胺后SWD时频动力学无明显变化。可以得出结论，修改后的Morlet小波变换的使用允许描述以前未检测到的SWD的主导节律的时频域中的动态的重要参数。(c)2005 Elsevier B. V.保留所有权利。
The continuous Morlet wavelet transform was used for the analysis of the time-frequency pattern of spike-wave discharges (SWD) as can be recorded in a genetic animal model of absence epilepsy (rats of the WAG/Rij strain). We developed a new wavelet transform that allows to obtain the time-frequency dynamics of the dominating rhythm during the discharges. SWD were analyzed pre- and post-administration of certain drugs. SWD recorded predrug demonstrate quite uniform time-frequency dynamics of the dominant rhythm. The beginning of the discharge has a short period with the highest frequency value (up to 15 Hz). Then the frequency decreases to 7-9 Hz and frequency modulation occurs during the discharge in this range with a period of 0.5-0.7 s. Specific changes of SWD time-frequency dynamics were found after the administration of psychoactive drugs, addressing different brain mediator and modulator systems. Short multiple SWDs appeared under low (0.5 mg/kg) doses of haloperidol, they are characterized by a fast frequency decrease to 5-6 Hz at the end of every discharge. The frequency of the dominant frequency of SWD was not stable in long lasting SWD after 1.0 mg/kg or more haloperidol: then two periodicities were found. Long lasting SWD seen after the administration of vigabatrin showed a stable frequency of the discharge. The EEG after Ketamin showed a distinct 5 s quasiperiodicity. No clear changes of time-frequency dynamics of SWD were found after perilamine. It can be concluded that the use of the modified Morlet wavelet transform allows to describe significant parameters of the dynamics in the time-frequency domain of the dominant rhythm of SWD that were not previously detected. (c) 2005 Elsevier B.V. All rights reserved.