Clinical uses of botulinum neurotoxins: current indications, limitations and future developments.
Clinical uses of botulinum neurotoxins: current indications, limitations and future developments.
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作者：
Chen S
肉毒杆菌神经毒素 (BoNT) 通过干扰神经元细胞中的囊泡融合和神经递质释放而引起弛缓性麻痹。 BoNT 是最广泛使用的治疗性蛋白质。 BoNT/A 早在 1989 年就被美国 FDA 批准用于治疗斜视、眼睑痉挛和半侧痉挛，随后用于治疗颈肌张力障碍、眉间纹、腋窝多汗症、慢性偏头痛和美容用途。由于其高效、持久的作用和令人满意的安全性，它已被经验性地用于各种眼科、胃肠道、泌尿科、骨科、皮肤科、分泌性疾病和疼痛性疾病。目前可用的 BoNT 疗法仅限于神经元适应症，需要定期注射，从而导致某些适应症产生免疫抵抗。最近对 BoNT 结构与功能关系的了解促使新型 BoNT 的工程设计，以扩展对非神经元系统的治疗干预并克服免疫抵抗问题。仍需要进行大量研究来改善和扩展 BoNT 的医疗用途。
Botulinum neurotoxins (BoNTs) cause flaccid paralysis by interfering with vesicle fusion and neurotransmitter release in the neuronal cells. BoNTs are the most widely used therapeutic proteins. BoNT/A was approved by the U.S. FDA to treat strabismus, blepharospam, and hemificial spasm as early as 1989 and then for treatment of cervical dystonia, glabellar facial lines, axillary hyperhidrosis, chronic migraine and for cosmetic use. Due to its high efficacy, longevity of action and satisfactory safety profile, it has been used empirically in a variety of ophthalmological, gastrointestinal, urological, orthopedic, dermatological, secretory, and painful disorders. Currently available BoNT therapies are limited to neuronal indications with the requirement of periodic injections resulting in immune-resistance for some indications. Recent understanding of the structure-function relationship of BoNTs prompted the engineering of novel BoNTs to extend therapeutic interventions in non-neuronal systems and to overcome the immune-resistance issue. Much research still needs to be done to improve and extend the medical uses of BoNTs.
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影响因子：
5
作者：
Bach-Rojecky, Lidija;Salkovic-Petrisic, Melita;Lackovic, Zdravko
通讯作者：
Lackovic, Zdravko
影响因子：
5
作者：
Aurora, Sheena K.;Winner, Paul;Turkel, Catherine C.
通讯作者：
Turkel, Catherine C.
影响因子：
64.8
作者：
Breidenbach, MA;Brunger, AT
通讯作者：
Brunger, AT
影响因子：
2.9
作者：
Arndt, JW;Yu, W;Stevens, RC
通讯作者：
Stevens, RC
DOI：
10.1016/j.anplas.2004.09.002
发表时间：
2004-10-01
期刊：
Annales de chirurgie plastique et esthetique
影响因子：
--
作者：
Ascher, B;Rossi, B
通讯作者：
Rossi, B