Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection
Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection
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DOI：
10.1126/science.280.5362.427
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发表时间：
1998-04-17
期刊：
影响因子：
56.9
通讯作者：
Lackner, AA
中科院分区：
文献类型：
--
作者：
Veazey, RS;DeMaria, M;Lackner, AA
人类和猿猴免疫缺陷病毒（HIV 和 SIV）在激活的记忆 CD4(+) T 细胞（肠道中丰富的一种细胞类型）中最佳复制。恒河猴的 SIV 感染导致感染后数天内肠道内 CD4(+) T 细胞的深度和选择性耗竭，然后外周淋巴组织发生任何此类变化。肠道中CD4(+) T细胞的损失与该部位大量单核细胞的生产性感染同时发生。肠道似乎是SIV 复制的主要目标，也是早期SIV 感染中CD4(+) T 细胞丢失的主要部位。
Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4(+) T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resulted in profound and selective depletion of CD4(+) T cells in the intestine within days of infection, before any such changes in peripheral lymphoid tissues. The loss of CD4(+) T cells in the intestine occurred coincident with productive infection of large numbers of mononuclear cells at this site. The intestine appears to be a major target for SIV replication and the major site of CD4(+) T cell loss in early SIV infection.