Argyrophilic grain disease: frequency and neuropathology in centenarians
Argyrophilic grain disease: frequency and neuropathology in centenarians
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DOI：
10.1007/s00401-006-0043-2
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发表时间：
2006-04-01
影响因子：
12.7
通讯作者：
Hashizume, Y
中科院分区：
文献类型：
--
作者：
Ding, ZT;Wang, Y;Hashizume, Y
嗜银颗粒病（AGD）是一种进行性脑退行性疾病，其患病率随着年龄的增长而增加。应用磷酸化tau蛋白（AT 8）免疫组化染色结合Gallyas-Braak染色和4 R tau特异性抗体（RD 4）免疫组化染色研究了32例百岁老人尸检脑AGD的特点。32名百岁老人中有10人被诊断为AGD，总频率为31.3%。痴呆组23例中9例（39.1%）有嗜银颗粒，而非痴呆组9例中1例（11.1%）有嗜银颗粒，两组比较差异有显著性（P < 0.05）。在阿尔茨海默病（AD）患者中，12例中有5例（41.7%）发现了AG。4例缠结型老年性痴呆（SDT）患者中有1例（25%）合并AGD。在痴呆患者中，由“纯”AGD引起的痴呆占13%（3/23）。我们的研究结果表明，有一个高频率的AGD在百岁老人。与以前的研究一致，我们支持年龄可能是AGD的危险因素之一的观点。
Argyrophilic grain disease (AGD) is a progressive degenerative disease of the human brain, the prevalence of which increases with advancing age. The features of AGD in autopsied brains from 32 centenarians were studied using phosphorylated tau (AT8) immunostaining combined with Gallyas-Braak staining and 4R tau-specific antibody (RD4) immunostaining. Ten of 32 centenarians were diagnosed as AGD, yielding an overall frequency of 31.3%. In the demented group, nine (39.1%) of 23 cases were found with argyrophilic grains (AGs), while in the non-demented group, AGs were found in only one (11.1%) of nine cases, the difference between them being significant (P < 0.05). Among the cases with Alzheimer's disease (AD), five (41.7%) of 12 were found with AGs. One (25%) of four cases with senile dementia with tangles (SDT) also suffered from AGD. Dementia caused by "pure" AGD accounted for 13% (3/23) among demented subjects. Our findings indicated that there is a high frequency of AGD in centenarians. In agreement with previous studies, we favor the view that age may be one of the risk factors for AGD.