Finding MEMO-Emerging Evidence for MEMO1's Function in Development and Disease.
Finding MEMO-Emerging Evidence for MEMO1's Function in Development and Disease.
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DOI：
10.3390/genes11111316
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发表时间：
2020-11-06
期刊：
影响因子：
3.5
通讯作者：
Van Otterloo E
中科院分区：
文献类型：
--
作者：
Schotanus MD;Van Otterloo E
尽管在整个动物界中都是保守的，但由 ERBB2 驱动细胞运动 1 或 MEMO1 基因介体编码的蛋白质直到最近才成为人们关注的焦点。正如它的名字一样，MEMO1 最初是从与 ERBB2 受体结合的分子的蛋白质组学筛选中出现的，并被发现是受体激活后有效细胞迁移所必需的。虽然最初被置于乳腺癌转移的背景下（一种病理状态，为人们对 MEMO1 的细胞作用提供了深入的了解），但 MEMO1 的功能后来扩展到涵盖其他癌细胞类型、胚胎发生过程中的发育过程以及成人器官系统的稳态调节。由于 MEMO1 的深度保守性，多种模式生物已经能够揭示这种多用途蛋白质的生物学方面。范围从细胞水平（例如，受体信号传导、细胞骨架调节、氧化还原通量）到有机体水平（例如，矿化和矿物质稳态、神经/胶质细胞生成、血管生成）水平。尽管这些方面出现在众多生物和人类疾病过程的交叉点上，但它们如何以及是否相互关联仍有待解决。在这里，我们回顾了我们目前对这种“神秘”分子的理解、它在发育和疾病中的作用以及这些先前研究中出现的开放性问题。
Although conserved throughout animal kingdoms, the protein encoded by the gene Mediator of ERBB2 Driven Cell Motility 1 or MEMO1, has only recently come into focus. True to its namesake, MEMO1 first emerged from a proteomic screen of molecules bound to the ERBB2 receptor and was found to be necessary for efficient cell migration upon receptor activation. While initially placed within the context of breast cancer metastasis—a pathological state that has provided tremendous insight into MEMO1′s cellular roles—MEMO1′s function has since expanded to encompass additional cancer cell types, developmental processes during embryogenesis and homeostatic regulation of adult organ systems. Owing to MEMO1′s deep conservation, a variety of model organisms have been amenable to uncovering biological facets of this multipurpose protein; facets ranging from the cellular (e.g., receptor signaling, cytoskeletal regulation, redox flux) to the organismal (e.g., mineralization and mineral homeostasis, neuro/gliogenesis, vasculogenesis) level. Although these facets emerge at the intersection of numerous biological and human disease processes, how and if they are interconnected remains to be resolved. Here, we review our current understanding of this ‘enigmatic’ molecule, its role in development and disease and open questions emerging from these previous studies.
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影响因子：
64.8
作者：
Iossifov, Ivan;O'Roak, Brian J.;Sanders, Stephan J.;Ronemus, Michael;Krumm, Niklas;Levy, Dan;Stessman, Holly A.;Witherspoon, Kali T.;Vives, Laura;Patterson, Karynne E.;Smith, Joshua D.;Paeper, Bryan;Nickerson, Deborah A.;Dea, Jeanselle;Dong, Shan;Gonzalez, Luis E.;Mandell, Jeffrey D.;Mane, Shrikant M.;Murtha, Michael T.;Sullivan, Catherine A.;Walker, Michael F.;Waqar, Zainulabedin;Wei, Liping;Willsey, A. Jeremy;Yamrom, Boris;Lee, Yoon-ha;Grabowska, Ewa;Dalkic, Ertugrul;Wang, Zihua;Marks, Steven;Andrews, Peter;Leotta, Anthony;Kendall, Jude;Hakker, Inessa;Rosenbaum, Julie;Ma, Beicong;Rodgers, Linda;Troge, Jennifer;Narzisi, Giuseppe;Yoon, Seungtai;Schatz, Michael C.;Ye, Kenny;McCombie, W. Richard;Shendure, Jay;Eichler, Evan E.;State, Matthew W.;Wigler, Michael
通讯作者：
Wigler, Michael
影响因子：
4
作者：
Chugh P;Paluch EK
通讯作者：
Paluch EK
DOI：
10.1186/bcr2839
发表时间：
2011-03-04
期刊：
Breast cancer research : BCR
影响因子：
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作者：
Hannafon BN;Sebastiani P;de las Morenas A;Lu J;Rosenberg CL
通讯作者：
Rosenberg CL
影响因子：
4.8
作者：
Haenzi, Barbara;Bonny, Olivier;Hynes, Nancy E.
通讯作者：
Hynes, Nancy E.
影响因子：
7.7
作者：
Ewald, Collin Yves;Hourihan, John M.;Hynes, Nancy E.
通讯作者：
Hynes, Nancy E.