Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid Tumours In Vivo.
Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid Tumours In Vivo.
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DOI：
10.7150/thno.11918
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发表时间：
2016
期刊：
影响因子：
12.4
通讯作者：
Al-Jamal KT
中科院分区：
文献类型：
--
作者：
Bai J;Wang JT;Rubio N;Protti A;Heidari H;Elgogary R;Southern P;Al-Jamal WT;Sosabowski J;Shah AM;Bals S;Pankhurst QA;Al-Jamal KT
三模成像磁性纳米胶囊，包裹着疏水性的超顺磁性氧化铁纳米颗粒，被配制成并用于在荷瘤小鼠静脉注射后对实体肿瘤进行磁性靶向。工程磁性聚合物纳米胶囊m-NCS的大小约为200 nm，Zeta电位为负，呈球形。超顺磁性氧化铁纳米粒子在m-NC中的载药率为~100%。当静磁场作用于肿瘤1小时时，肿瘤摄取在1小时和24小时时分别增加了~3倍和~2.2倍。M-NCs具有多种成像探针(如吲哚青绿、超顺磁性氧化铁纳米颗粒和铟-111)，能够在体内进行三模式成像(荧光/磁共振/核成像)。使用三模式成像是为了克服单模式成像的内在局限性，并提供关于肿瘤内纳米载体空间分布的补充信息。这项研究的重要发现可能为将新型磁性响应纳米材料用于磁性药物靶向与多模式成像相结合开辟新的研究前景。
Triple-modal imaging magnetic nanocapsules, encapsulating hydrophobic superparamagnetic iron oxide nanoparticles, are formulated and used to magnetically target solid tumours after intravenous administration in tumour-bearing mice. The engineered magnetic polymeric nanocapsules m-NCs are ~200 nm in size with negative Zeta potential and shown to be spherical in shape. The loading efficiency of superparamagnetic iron oxide nanoparticles in the m-NC was ~100%. Up to ~3- and ~2.2-fold increase in tumour uptake at 1 and 24 h was achieved, when a static magnetic field was applied to the tumour for 1 hour. m-NCs, with multiple imaging probes (e.g. indocyanine green, superparamagnetic iron oxide nanoparticles and indium-111), were capable of triple-modal imaging (fluorescence/magnetic resonance/nuclear imaging) in vivo. Using triple-modal imaging is to overcome the intrinsic limitations of single modality imaging and provides complementary information on the spatial distribution of the nanocarrier within the tumour. The significant findings of this study could open up new research perspectives in using novel magnetically-responsive nanomaterials in magnetic-drug targeting combined with multi-modal imaging.