Cognitive impairment and medial temporal lobe structure in young adults with a depressive episode
Cognitive impairment and medial temporal lobe structure in young adults with a depressive episode
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DOI：
10.1016/j.jad.2018.05.015
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发表时间：
2018-09-01
影响因子：
6.6
通讯作者：
Buthut, Maria
中科院分区：
文献类型：
--
作者：
Donix, Markus;Haussmann, Robert;Buthut, Maria
背景资料：认知缺陷在抑郁发作患者中很常见，尽管其发展和严重程度的预测因素仍然难以捉摸。方法：对27例青年抑郁症患者进行高分辨率磁共振成像、皮质展开数据分析和主、客观认知能力的综合评估（平均年龄：29.0 ± 5.8岁）和23名无抑郁症病史但有遗忘性轻度认知障碍的老年参与者（68.5 +/- 6.6岁）或认知正常（65.2 +/- 8.7岁）。海马旁区厚度减少，嗅周皮质和梭状皮质仅在有抑郁发作和可测量的认知功能障碍的年轻患者中与主观记忆缺陷相关。impairment.Limitations:长期的纵向数据将是可取的，以确定与抑郁症患者的认知功能障碍的轨迹，或没有皮质结构changes.Conclusions：临床上显着的认知功能障碍的存在下，在年轻人的抑郁发作可能会确定一个患者人群与海马外皮质变薄。
Background: Cognitive deficits are common in patients with a depressive episode although the predictors for their development and severity remain elusive. We investigated whether subjective and objective cognitive impairment in young depressed adults would be associated with cortical thinning in medial temporal subregions.Methods: High-resolution magnetic resonance imaging, cortical unfolding data analysis, and comprehensive assessments of subjective and objective cognitive abilities were performed on 27 young patients with a depressive episode (mean age: 29.0 +/- 5.8 years) and 23 older participants without a history of a depressive disorder but amnestic mild cognitive impairment (68.5 +/- 6.6 years) or normal cognition (65.2 +/- 8.7 years).Results: Thickness reductions in parahippocampal, perirhinal and fusiform cortices were associated with subjective memory deficits only among young patients with a depressive episode and a measurable cognitive impairment.Limitations: Long-term longitudinal data would be desirable to determine the trajectories of cognitive impairment associated with depression in patients with or without cortical structure changes.Conclusions: The presence of clinically significant cognitive deficits in young people with a depressive episode may identify a patient population with extrahippocampal cortical thinning.