THYMUS IN MICE OF STRAIN 129/J, STUDIED WITH ELECTRON MICROSCOPE
THYMUS IN MICE OF STRAIN 129/J, STUDIED WITH ELECTRON MICROSCOPE
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DOI：
10.1002/aja.1001120102
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发表时间：
1963-01-01
影响因子：
--
通讯作者：
CLARK, SL
中科院分区：
文献类型：
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作者：
CLARK, SL
年轻成年雄性小鼠的胸腺是一个实性上皮器官，淋巴样细胞浸润，并被纤细的网状纤维和血管穿透。上皮细胞的特征是细胞质张力原纤维和连接相邻细胞的桥粒。在上皮与结缔组织交界处，如小叶周围、沿着网状纤维和血管，都有基底膜。未见Hassal小体，但有少量上皮细胞排列于腺泡内，并有纤毛。一些上皮细胞含有小而致密的颗粒或空泡簇，其中充满无定形物质，这两种物质都可能代表分泌产物。在这些成年动物中未观察到上皮细胞产生淋巴细胞的迹象。存在含有大量内含物和变性淋巴细胞的大巨噬细胞，但不具有上皮细胞的显著特征。大多数淋巴样细胞位于上皮细胞之间，通过上皮细胞和基底膜的连续屏障与结缔组织隔开。这可能是阻止抗原和活体染料渗透到胸腺实质的血-胸腺屏障。发现小淋巴细胞堵塞上皮基底膜的间隙，好像通过它迁移，其他人渗透到具有厚内皮细胞的特殊小静脉壁。这种血管以前在胸腺中没有描述过，似乎是淋巴细胞在淋巴组织和血流之间迁移的部位。考虑到胸腺在免疫能力的发展中起着必要作用的生理学证据，有人提出，从胸腺的隔离环境迁移的淋巴细胞具有在淋巴系统中发挥功能的独特潜力。
The thymus in young adult male mice is a solid epithelial organ, infiltrated with lymphoid cells and perforated by delicate reticular fibers and blood vessels. The epithelial cells, are characterized by cytoplasmic tonofibrils and desmosomes connecting adjacent cells. Wherever the epithelium bordered connective tissue, as at the periphery of the lobules and along reticular fibers and blood vessels, there was a basement membrane. No Hassal''s corpuscles were seen, but a few epithelial cells were arranged in acini and possessed cilia. Some epithelial cells contained small dense granules or clusters of vacuoles filled with amorphous material, either of which might represent a secretory product No signs that epithelial cells produce lymphocytes were observed in these adult animals. There were large macrophages containing numerous inclusions and degenerating lymphocytes, but possessing none of the distinctive features of epithelial cells. Most of the lymphoid cells lay between epithelial cells in a space separated from connective tissue by a continuous barrier of epithelial cells and basement membrane. This probably is the hemato-thymic barrier that prevents antigens and vital dyes from penetrating into the thymic parenchyma. Small lymphocytes were found occluding gaps in the epithelial basement membrane, as if migrating through it, and others infiltrated the walls of peculiar venules with thick endothelial cells. This type of vessel, not described previously in the thymus, seems to be a site for migration of lymphocytes between lymphoid tissues and the blood stream. In considering the physiological evidence that the thymus plays a necessary role in the development of immunological competence, it was proposed that lymphocytes migrating from the secluded environment of the thymus possess unique potentialities for function in the lymphoid system.