A provegetarian food pattern and reduction in total mortality in the Prevencion con Dieta Mediterranea (PREDIMED) study
A provegetarian food pattern and reduction in total mortality in the Prevencion con Dieta Mediterranea (PREDIMED) study
复制标题
DOI：
10.3945/ajcn.113.071431
复制
发表时间：
2014-07-01
影响因子：
7.1
通讯作者：
Estruch, Ramon
中科院分区：
文献类型：
--
作者：
Martinez-Gonzalez, Miguel A.;Sanchez-Tainta, Ana;Estruch, Ramon
背景：素食与死亡率降低有关。因为纯素食可能不容易被许多人接受，所以优先食用植物性食物将是一个更容易理解的信息。A provegetarian food pattern（FP）emphasizing preference for plant derivatives might reduce all-cause mortality.Objective：The objective was to identify association between a priori defined provegetarian FP and all-cause mortality.Design：We follow 7216 participants（57% women; meanage age：67 y）at high cardiovascular risk for a median of 4.8 y.在基线和此后每年进行一次经验证的137项半定量食物频率问卷调查。水果、蔬菜、坚果、谷物、豆类、橄榄油和土豆的权重为正。添加的动物脂肪、蛋、鱼、奶制品和肉或肉制品的权重为负。能量调整的五分位数用于分配构建亲素食FP的分数（范围：12-60分）。死亡证实的医疗记录和国家死亡Index.Results审查：有323例死亡在随访期间（76心血管原因，130癌症，117非癌症，非心血管原因）。与素食者FP的基线一致性较高与死亡率较低相关（多变量校正HR>= 40，
Background: Vegetarian diets have been associated with reduced mortality. Because a pure vegetarian diet might not easily be embraced by many individuals, consuming preferentially plant-derived foods would be a more easily understood message. A provegetarian food pattern (FP) emphasizing preference for plant-derived foods might reduce all-cause mortality.Objective: The objective was to identify the association between an a priori defined provegetarian FP and all-cause mortality.Design: We followed 7216 participants (57% women; mean age: 67 y) at high cardiovascular risk for a median of 4.8 y. A validated 137-item semiquantitative food-frequency questionnaire was administered at baseline and yearly thereafter. Fruit, vegetables, nuts, cereals, legumes, olive oil, and potatoes were positively weighted. Added animal fats, eggs, fish, dairy products, and meats or meat products were negatively weighted. Energy-adjusted quintiles were used to assign points to build the provegetarian FP (range: 12-60 points). Deaths were confirmed by review of medical records and the National Death Index.Results: There were 323 deaths during the follow-up period (76 from cardiovascular causes, 130 from cancer, 117 for noncancer, noncardiovascular causes). Higher baseline conformity with the provegetarian FP was associated with lower mortality (multivariable-adjusted HR for >= 40 compared with