The projected effect of risk factor reduction on Alzheimer's disease prevalence.
The projected effect of risk factor reduction on Alzheimer's disease prevalence.
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DOI：
10.1016/s1474-4422(11)70072-2
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发表时间：
2011-09
期刊：
影响因子：
48
通讯作者：
Yaffe, Kristine
中科院分区：
文献类型：
--
作者：
Barnes, Deborah E.;Yaffe, Kristine
目前全球约有3390万阿尔茨海默病（AD）患者，预计在未来40年内患病率将增加两倍。本综述的目的是总结关于7个潜在可改变的AD风险因素的证据：糖尿病、中年高血压、中年肥胖、吸烟、抑郁、低教育程度和缺乏身体活动。此外，我们通过计算人群归因风险（PAR，归因于给定因素的病例百分比）以及全球和美国风险因素降低10%和25%可能预防的AD病例数量，预测了风险因素降低对AD患病率的影响。这些因素共同导致了全球（1720万）和美国（290万）AD病例的一半。所有七个风险因素减少10%-25%，可能会在全球范围内预防多达110万至300万例病例，在美国预防184，000至492，000例病例。
There are currently approximately 33.9 million individuals with Alzheimer's disease (AD) worldwide, and prevalence is expected to triple over the next 40 years. The goal of this review was to summarize the evidence regarding seven potentially modifiable AD risk factors: diabetes, mid-life hypertension, mid-life obesity, smoking, depression, low educational attainment and physical inactivity. In addition, we projected the impact of risk factor reduction on AD prevalence by calculating population attributable risks (PARs, the percent of cases attributable to a given factor) and the number of AD cases that could potentially be prevented by 10% and 25% risk factor reductions worldwide and in the US. Together, these factors contributed to up to half of AD cases globally (17.2 million) and in the US (2.9 million). A 10%–25% reduction in all seven risk factors could potentially prevent as many as 1.1–3.0 million cases worldwide and 184,000–492,000 cases in the US.