Decline in reproductive success, sex reversal, and developmental alterations in Japanese medaka (Oryzias latipes) after continuous exposure to octylphenol.
Decline in reproductive success, sex reversal, and developmental alterations in Japanese medaka (Oryzias latipes) after continuous exposure to octylphenol.
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DOI：
10.1006/eesa.2001.2123
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发表时间：
2002-03
影响因子：
6.8
通讯作者：
Susanne Knörr;T. Braunbeck
中科院分区：
文献类型：
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作者：
Susanne Knörr;T. Braunbeck
在受精后2 - 4小时，日本稻鳉（Oryzias latipes）连续暴露于浓度为0、2、20和50 μ g/L的辛基酚，浓度为0.01 /千的二甲亚砜和浓度为100 ng/L的17 -雌二醇中直至成熟。暴露于bb0或=2微克/升的辛基酚可使孵化前后的死亡率增加20-30%。暴露于50微克/升辛基酚和阳性对照的鱼的生长显著下降。性别比例从对照组的42:58（雌性：雄性）变化到50微克/升辛基酚时的57:40，暴露于50微克/升辛基酚和17 -雌二醇的medaka分别有3%和4%发育了睾丸-卵子。在交叉交配实验中，暴露的雄性与对照雌性交配导致受精率比对照低11%。结果表明，持续暴露于辛基酚会引起多种生殖效应，这可能与辛基酚的异雌激素潜能有关。
Japanese medaka (Oryzias latipes) were continuously exposed to concentrations of 0, 2, 20, and 50 microg/L octylphenol, 0.01 per thousand dimethyl sulfoxide, and 100 ng/L 17beta-estradiol from 2 to 4 h postfertilization until maturity. Exposure to > or =2 microg/L octylphenol caused a 20-30% increase in mortality both before and after hatch. Growth was significantly decreased in fish exposed to 50 microg/L octylphenol and in the positive control. Sex ratio changed from 42:58 (females:males) in controls to 57:40 at 50 microg/L octylphenol, and 3 and 4% of the medaka exposed to 50 microg/L octylphenol and 17beta-estradiol developed testes-ova. In cross-mating experiments, mating of exposed males with control females resulted in an up to 11% lower fertilization rate than in controls. Results indicate that continuous exposure to octylphenol causes a broad variety of reproductive effects, which can be correlated with the xenoestrogenic potential of octylphenol.