Regulation of facial morphogenesis by endothelin signaling: insights from mice and fish.
Regulation of facial morphogenesis by endothelin signaling: insights from mice and fish.
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DOI：
10.1002/ajmg.a.33568
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发表时间：
2010-12
影响因子：
2
通讯作者：
Schilling, Thomas F.
中科院分区：
文献类型：
--
作者：
Clouthier, David E.;Garcia, Elvin;Schilling, Thomas F.
关键词：
颅面形态发生是通过一系列复杂的发育过程完成的，其中大部分起始于咽弓内的神经嵴细胞。来自周围环境的局部图案线索诱导神经嵴细胞内的基因表达，导致形成一组不同的骨骼元素。内皮素-1（Edn 1）是确定第一咽弓下颌部分内神经嵴细胞身份的主要信号之一。通过其同源受体内皮素-A受体的信号传导对弓腹侧/远侧部分（下颌）的图案化至关重要，并且还与Hox基因一起参与更多后弓的图案化。Edn 1/Ednra信号在小鼠和斑马鱼之间高度保守，这两个物种的遗传分析为负责建立颅面复合体的模式线索以及面部出生缺陷综合征的遗传基础提供了互补的见解。
Craniofacial morphogenesis is accomplished through a complex set of developmental events, most of which are initiated in neural crest cells within the pharyngeal arches. Local patterning cues from the surrounding environment induce gene expression within neural crest cells, leading to formation of a diverse set of skeletal elements. Endothelin-1 (Edn1) is one of the primary signals that establish the identities of neural crest cells within the mandibular portion of the first pharyngeal arch. Signaling through its cognate receptor, the endothelin-A receptor, is critical for patterning the ventral/distal portion of the arch (lower jaw) and also participates with Hox genes in patterning more posterior arches. Edn1/Ednra signaling is highly conserved between mouse and zebrafish, and genetic analyses in these two species have provided complementary insights into the patterning cues responsible for establishing the craniofacial complex as well as the genetic basis of facial birth defect syndromes.
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影响因子：
11.8
作者：
Arnold, Michael A.;Kim, Yuri;Olson, Eric N.
通讯作者：
Olson, Eric N.
DOI：
10.1073/pnas.2335885100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Chakrabarti, S;Liu, NJ;Gintzler, AR
通讯作者：
Gintzler, AR
DOI：
10.1073/pnas.93.2.867
发表时间：
1996-01-23
影响因子：
11.1
作者：
Gariepy, CE;Cass, DT;Yanagisawa, M
通讯作者：
Yanagisawa, M
影响因子：
2.7
作者：
Barbosa, Ana C.;Funato, Noriko;Yanagisawa, Hiromi
通讯作者：
Yanagisawa, Hiromi
影响因子：
2.7
作者：
Clouthier, DE;Williams, SC;Yanagisawa, M
通讯作者：
Yanagisawa, M