The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation.
The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation.
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DOI：
10.1016/j.bbamem.2013.07.016
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发表时间：
2014-02
期刊：
影响因子：
--
通讯作者：
Upadhyaya A
中科院分区：
文献类型：
--
作者：
Song W;Liu C;Upadhyaya A
肌动蛋白细胞骨架是一个动态的细胞网络，以其在细胞形态和运动中的功能而闻名。最近使用高分辨率和实时成像技术的研究表明，肌动蛋白在信号转导中发挥着关键作用，主要是通过调节膜相关受体和信号分子的动力学和组织。这篇综述总结了我们到目前为止所了解到的关于肌动蛋白细胞骨架在B细胞受体(BCR)信号转导中的调节作用。BCR的激活是由表面BCR和皮质肌动蛋白网络之间的密切协调启动和调节的。肌动蛋白细胞骨架参与调节BCR对抗原刺激的信号阈值，BCR信号活性的动力学和放大，以及信号下调的时间和动力学。肌动蛋白通过控制BCR簇和BCR信号复合体形成的动力学、大小、亚细胞位置和性质来发挥其调节功能。皮质肌动蛋白网络通过最初从质膜上分离、拆解和随后重新组装成新的肌动蛋白结构来重塑，以响应抗原刺激。信号响应性肌动蛋白调节因子将BCR的刺激和抑制信号转化为一系列的肌动蛋白重塑事件，通过调节表面BCR的横向运动和空间组织来增强信号的激活和下调。了解B细胞中肌动蛋白介导的信号调控的机制将有助于我们探索B细胞特异性的肌动蛋白细胞骨架操作，作为B细胞介导的自身免疫和B细胞癌的治疗方法。本文是一期特刊的一部分，题为：细胞骨架与膜通道、受体和转运体之间的相互影响。
The actin cytoskeleton is a dynamic cellular network known for its function in cell morphology and motility. Recent studies using high resolution and real time imaging techniques have revealed that actin plays a critical role in signal transduction, primarily by modulating the dynamics and organization of membrane-associated receptors and signaling molecules. This review summarizes what we have learned so far about a regulatory niche of the actin cytoskeleton in the signal transduction of the B cell receptor (BCR). The activation of the BCR is initiated and regulated by a close coordination between the dynamics of surface BCRs and the cortical actin network. The actin cytoskeleton is involved in regulating the signaling threshold of the BCR to antigenic stimulation, the kinetics and amplification of BCR signaling activities, and the timing and kinetics of signaling downregulation. Actin exerts its regulatory function by controlling the kinetics, magnitude, subcellular location, and nature of BCR clustering and BCR signaling complex formation at every stage of signaling. The cortical actin network is remodeled by initial detachment from the plasma membrane, disassembly and subsequent reassembly into new actin structures in response to antigenic stimulation. Signaling responsive actin regulators translate BCR stimulatory and inhibitory signals into a series of actin remodeling events, which enhance signaling activation and down-regulation by modulating the lateral mobility and spatial organization of surface BCR. The mechanistic understanding of actinmediated signaling regulation in B cells will help us explore B cell-specific manipulations of the actin cytoskeleton as treatments for B cell-mediated autoimmunity and B cell cancer. This article is part of a Special Issue entitled: Reciprocal influences between cell cytoskeleton and membrane channels, receptors and transporters.
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DOI：
10.1073/pnas.77.8.4979
发表时间：
1980-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
BACHVAROFF, RJ;MILLER, F;RAPAPORT, FT
通讯作者：
RAPAPORT, FT
影响因子：
32.4
作者：
Arana, Eloisa;Vehlow, Anne;Batista, Facundo D.
通讯作者：
Batista, Facundo D.
影响因子：
21.3
作者：
Amann, KJ;Pollard, TD
通讯作者：
Pollard, TD
影响因子：
4.4
作者：
Cheng, PC;Brown, BK;Pierce, SK
通讯作者：
Pierce, SK
影响因子：
32.4
作者：
Carrasco, YR;Fleire, SJ;Batista, FD
通讯作者：
Batista, FD