The structure and function of GGAs, the traffic controllers at the TGN sorting crossroads.
The structure and function of GGAs, the traffic controllers at the TGN sorting crossroads.
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GGA（TGN 分拣十字路口的交通控制器）的结构和功能。
DOI：
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发表时间：
2003
影响因子：
1.5
通讯作者：
S. Wakatsuki
中科院分区：
文献类型：
--
作者：
K. Nakayama;S. Wakatsuki
GGAS(Golgi-Locating，Gamma-Adaptin Ear Homology DOMAIN，ARF-BINDING Proteins)是一类从酵母菌到人类都保守的单体蛋白家族。在过去四年中公布的数据提供了GAS的本地化、领域组织和结构-职能关系的详细图景。GGAs有四个保守的功能结构域，每个结构域都与货物蛋白相互作用，包括甘露糖6-磷酸受体、小GTP酶ARF、网状蛋白或辅助蛋白包括Rabaptin-5和Gamma-Synergin。GGAs与接合蛋白复合体AP-1一起或独立于接合蛋白复合体AP-1，调节货物蛋白，如甘露糖6-磷酸受体，从反高尔基网络到由笼蛋白包裹的小泡介导的内体的选择性运输。
GGAs (Golgi-localizing, gamma-adaptin ear homology domain, ARF-binding proteins) are a family of monomeric clathrin adaptor proteins that are conserved from yeasts to humans. Data published during the past four years have provided detailed pictures of the localization, domain organization and structure-function relationships of GGAs. GGAs possess four conserved functional domains, each of which interacts with cargo proteins including mannose 6-phosphate receptors, the small GTPase ARF, clathrin, or accessory proteins including Rabaptin-5 and gamma-synergin. Together with or independent of the adaptor protein complex AP-1, GGAs regulate selective transport of cargo proteins, such as mannose 6-phosphate receptors, from the trans-Golgi network to endosomes mediated by clathrin-coated vesicles.
AP-1 连接体复合物与不含 6-磷酸甘露糖受体的跨高尔基体网络膜高亲和力结合。
影响因子：
3.3
作者：
Zhu,Y;Traub,LM;Kornfeld,S
通讯作者：
Kornfeld,S
人类 GGA1 GAT 结构域的晶体结构。
DOI：
10.1021/bi034334n
发表时间：
2003
期刊：
Biochemistry.
影响因子：
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作者：
Zhu,Guangyu;Zhai,Peng;He,Xiangyuan;Terzyan,Simon;Zhang,Rongguang;Joachimiak,Andrzej;Tang,Jordan;Zhang,XuejunC
通讯作者：
Zhang,XuejunC