Apparatus for Histological Validation of In Vivo and Ex Vivo Magnetic Resonance Imaging of the Human Prostate.
Apparatus for Histological Validation of In Vivo and Ex Vivo Magnetic Resonance Imaging of the Human Prostate.
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DOI：
10.3389/fonc.2017.00047
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发表时间：
2017
影响因子：
4.7
通讯作者：
Panagiotaki E
中科院分区：
文献类型：
--
作者：
Bourne RM;Bailey C;Johnston EW;Pye H;Heavey S;Whitaker H;Siow B;Freeman A;Shaw GL;Sridhar A;Mertzanidou T;Hawkes DJ;Alexander DC;Punwani S;Panagiotaki E
本文描述了帮助对人类前列腺磁共振成像研究进行组织学验证的装置。该设备包括 3D 打印的患者专用模具，有助于体内和离体成像、原位组织固定和组织切片，同时器官变形最小。该模具和专用容器包括 MRI 可见标志，以实现一致的组织定位并最大限度地减少图像配准复杂性。高空间分辨率离体成像有助于体内 MRI 和组织病理学数据的注册。
This article describes apparatus to aid histological validation of magnetic resonance imaging studies of the human prostate. The apparatus includes a 3D-printed patient-specific mold that facilitates aligned in vivo and ex vivo imaging, in situ tissue fixation, and tissue sectioning with minimal organ deformation. The mold and a dedicated container include MRI-visible landmarks to enable consistent tissue positioning and minimize image registration complexity. The inclusion of high spatial resolution ex vivo imaging aids in registration of in vivo MRI and histopathology data.