Grid Cells and Place Cells: An Integrated View of their Navigational and Memory Function.
Grid Cells and Place Cells: An Integrated View of their Navigational and Memory Function.
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DOI：
10.1016/j.tins.2015.10.004
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发表时间：
2015-12
影响因子：
15.9
通讯作者：
Lisman J
中科院分区：
文献类型：
--
作者：
Sanders H;Rennó-Costa C;Idiart M;Lisman J
关于海马/内嗅系统已经了解了很多，但缺乏对其各部分如何以综合方式工作的概述。一个问题是关于内嗅网格细胞的功能。我们在这里提出，它们的基本功能是提供一个坐标系统，用于在海马体中产生思维旅行，这是一个访问与即将到来的位置的关联的过程。我们进一步提出，心灵旅行发生在每个θ周期的后半部分。相比之下，每个θ周期的前半部分用于使用来自外侧内嗅皮层（LEC）的感觉信息和来自内侧内嗅皮层（MEC）的路径整合信息来计算当前位置。该模型解释了为什么病变可以消除海马相位岁差，但不能消除定位场。
Much has been learned about the hippocampal/entorhinal system, but an overview of how its parts work in an integrated way is lacking. One question regards the function of entorhinal grid cells. We propose here that their fundamental function is to provide a coordinate system for producing mind-travel in the hippocampus, a process that accesses associations with upcoming positions. We further propose that mind-travel occurs during the second half of each theta cycle. By contrast, the first half of each theta cycle is devoted to computing current position using sensory information from the lateral entorhinal cortex (LEC) and path integration information from the medial entorhinal cortex (MEC). This model explains why lesions can abolish hippocampal phase precession but not place fields.