Nicotine and behavioral markers of risk for schizophrenia:: A double-blind, placebo-controlled, cross-over study
Nicotine and behavioral markers of risk for schizophrenia:: A double-blind, placebo-controlled, cross-over study
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DOI：
10.1016/s0893-133x(02)00372-x
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发表时间：
2002-12-01
影响因子：
7.6
通讯作者：
Lal, S
中科院分区：
文献类型：
--
作者：
Dépatie, L;O'Driscoll, GA;Lal, S
我们研究了尼古丁对精神分裂症风险的三种行为标志物的影响：持续注意力（使用连续操作任务（CPT））、反向眼跳表现以及平稳追踪。平稳追踪在两种条件下进行研究，一种是注意力增强的情况（监测目标变化），另一种是注意力未增强的情况（无监测）。15名精神分裂症患者和14名对照者采用双盲、安慰剂对照、交叉设计给予14毫克尼古丁贴片，并监测血浆尼古丁浓度。两组的尼古丁浓度相似。CPT命中数的组×药物交互作用（P <.02）表明，尼古丁改善了患者的持续注意力，但未改善对照者的持续注意力。尼古丁显著减少了两组的反向眼跳错误（p <.01）。追踪增益的药物×监测条件交互作用（p <.01）表明，尼古丁在无监测条件下同等地显著增加了患者和对照者的追踪增益，但在监测条件下未改善追踪。因此，追踪的改善可能是通过对注意力的影响而非对眼球运动功能本身的影响来介导的。在患者中，尼古丁对注意力改善的程度与眼动任务的改善相关。因此，尼古丁可能通过共同机制改善了精神分裂症风险的注意力和眼球运动标志物的表现。（C）2002年美国神经精神药理学院。由爱思唯尔科学公司出版。
We investigated the effect of nicotine on three behavioral markers of risk for schizophrenia: sustained attention (using the Continuous Performance Task (CPT)), antisaccade performance, and smooth pursuit. Smooth pursuit was investigated in two conditions, one in which attention was enhanced (monitoring target changes) and one in which attention was not enhanced (no monitoring). Patients with schizophrenia (n = 15) and controls (n = 14) were given a 14-mg nicotine patch in a double-blind, placebo-controlled, crossover design and plasma nicotine concentrations were monitored. Nicotine concentrations were similar in both groups. A Group X Drug interaction (P < .02) on CPT hits indicated that nicotine improved sustained attention in patients but not in controls. Nicotine significantly decreased antisaccade errors (p < .01) in both groups. A Drug X Monitoring condition interaction (p < .01) on pursuit gain indicated that nicotine significantly increased pursuit gain in the no-monitoring condition in patients and controls equally, but did not improve pursuit in the monitoring condition. Thus, improvement in pursuit may have been mediated via an effect on attention rather than by an effect on oculomotor function per se. In patients, the magnitude of improvement in attention on nicotine was correlated with the improvement on eye movement tasks. Thus, nicotine improves performance on both attention and oculomotor markers of risk for schizophrenia, possibly via common mechanisms. (C) 2002 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.