Metal-Free Cyclopropanol Ring-Opening C(sp3)-C(sp2) Cross-Couplings with Aryl Sulfoxides
Metal-Free Cyclopropanol Ring-Opening C(sp3)-C(sp2) Cross-Couplings with Aryl Sulfoxides
复制标题
无金属环丙醇开环 C(sp(3))-C(sp(2)) 与芳基亚砜的交叉偶联
DOI：
10.1021/acs.orglett.9b01908
复制
发表时间：
2019-07-19
期刊：
影响因子：
5.2
通讯作者：
Huang, Shenlin
中科院分区：
文献类型：
--
作者：
Chen, Dengfeng;Fu, Yuanyuan;Huang, Shenlin
本文报道了一种无金属催化的酮的β-芳基化/杂芳基化反应，该反应是在室温下通过环丙醇与芳基亚砜的有效开环偶联进行的。该协议显示了广泛的基板范围和有前途的可扩展性。此外，β-芳基化酮的效用通过各种后偶联转化和合成应用得到进一步证明。
A metal-free method for formal beta-arylation/heteroarylation of ketones through efficient cyclopropanol ring-opening cross-couplings with aryl sulfoxides at room temperature has been developed. This protocol shows a broad substrate scope and promising scalability. In addition, the utility of the beta-arylated ketones is further demonstrated through a variety of postcoupling transformations and synthetic applications.