TEMPERATURE ADAPTATION OF ENZYMES - ROLES OF FREE-ENERGY, ENTHALPY, AND ENTROPY OF ACTIVATION
TEMPERATURE ADAPTATION OF ENZYMES - ROLES OF FREE-ENERGY, ENTHALPY, AND ENTROPY OF ACTIVATION
复制标题
DOI：
10.1073/pnas.70.2.430
复制
发表时间：
1973-01-01
影响因子：
11.1
通讯作者：
SOMERO, GN
中科院分区：
文献类型：
--
作者：
LOW, PS;BADA, JL;SOMERO, GN
变温（冷血）物种的酶反应与鸟类和哺乳动物物种的酶反应在三个热力学活化参数（活化自由能（ΔG）、活化焓（ΔH）和活化熵（ΔS））的大小方面有所不同。在减少化学反应的ΔG“能量障碍”方面，变温酶比鸟类和哺乳动物的同源酶更有效。此外，在这两大类生物中，熵和熵对ΔG Δ的贡献的相对重要性是不同的。
The enzymic reactions of ectothermic (cold-blooded) species differ from those of avian and mammalian species in terms of the magnitudes of the three thermodynamic activation parameters, the free energy of activation (ΔG⧧), the enthalpy of activation (ΔH⧧), and the entropy of activation (ΔS⧧). Ectothermic enzymes are more efficient than the homologous enzymes of birds and mammals in reducing the ΔG⧧“energy barrier” to a chemical reaction. Moreover, the relative importance of the enthalpic and entropic contributions to ΔG⧧differs between these two broad classes of organisms.