Microscale distribution and dynamic surface tension of pulmonary surfactant normalize the recruitment of asymmetric bifurcating airways
Microscale distribution and dynamic surface tension of pulmonary surfactant normalize the recruitment of asymmetric bifurcating airways
复制标题
肺表面活性剂的微观分布和动态表面张力使不对称分叉气道的募集正常化
DOI：
10.1152/japplphysiol.00543.2016
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发表时间：
2017
影响因子：
3.3
通讯作者：
Gaver, Donald P.
中科院分区：
文献类型：
--
作者：
Yamaguchi, Eiichiro;Nolan, Liam P.;Gaver, Donald P.
我们研究了分叉几何形状、子代气道的不对称性、表面活性物质的分布以及物化性质对非对称分叉气道吸气的均匀性的影响。为此，我们建立了分叉气管的微流体理想化体外模型，通过该模型，我们可以独立地评估隆突位置和子气管的宽度和长度的影响。我们探讨了补给的均匀性及其与衬液动态表面张力的关系，并将这种行为与水力(PHYD)和毛细管(PCAP)压降相关联。这些研究证明了PCapin稳定再开放的非凡重要性，即使在高度不对称的系统中也是如此。肺表面活性物质的动态表面张力对这种稳定性是不可或缺的，因为它以一种速度依赖的方式调节PCapi。此外，表面活性剂在传播界面的分布可以通过将表面活性剂优先聚焦到特定的子气道来对招募稳定性产生非常大的影响。这表明，通过新的通风模式改变表面活性物质的分布可能有助于诱导均匀招募的肺，帮助气体交换，并减少呼吸机诱导的肺损伤。新与注意肺表面活性物质的动态表面张力对于不对称分叉气道招募的一致性是不可或缺的，因为它以一种速度依赖的方式调节毛细血管压降。此外，表面活性剂在传播界面的分布可以通过将表面活性剂优先聚焦到特定的子气道来对招募稳定性产生非常大的影响。这表明，通过新的呼吸模式改变表面活性物质的分布可能有助于诱导均匀招募的肺，减少呼吸机诱导的肺损伤。
We investigate the influence of bifurcation geometry, asymmetry of daughter airways, surfactant distribution, and physicochemical properties on the uniformity of airway recruitment of asymmetric bifurcating airways. To do so, we developed microfluidic idealized in vitro models of bifurcating airways, through which we can independently evaluate the impact of carina location and daughter airway width and length. We explore the uniformity of recruitment and its relationship to the dynamic surface tension of the lining fluid and relate this behavior to the hydraulic (PHyd) and capillary (PCap) pressure drops. These studies demonstrate the extraordinary importance of PCapin stabilizing reopening, even in highly asymmetric systems. The dynamic surface tension of pulmonary surfactant is integral to this stability because it modulates PCapin a velocity-dependent manner. Furthermore, the surfactant distribution at the propagating interface can have a very large influence on recruitment stability by focusing surfactant preferentially to specific daughter airways. This implies that modification of the surfactant distribution through novel modes of ventilation could be useful in inducing uniformly recruited lungs, aiding in gas exchange, and reducing ventilator-induced lung injury.NEW & NOTEWORTHYThe dynamic surface tension of pulmonary surfactant is integral to the uniformity of asymmetric bifurcation airway recruitments because it modulates capillary pressure drop in a velocity-dependent manner. Also, the surfactant distribution at the propagating interface can have a very large influence on recruitment stability by focusing surfactant preferentially to specific daughter airways. This implies that modification of the surfactant distribution through novel modes of ventilation could be useful in inducing uniformly recruited lungs, reducing ventilator-induced lung injury.