Outcomes of oral squamous cell carcinoma in Taiwan after surgical therapy: Factors affecting survival
Outcomes of oral squamous cell carcinoma in Taiwan after surgical therapy: Factors affecting survival
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DOI：
10.1016/s0278-2391(03)00149-6
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发表时间：
2003-07-01
影响因子：
1.9
通讯作者：
Chang, RCS
中科院分区：
文献类型：
--
作者：
Lo, WL;Kao, SY;Chang, RCS
目的：本研究的目的是确定哪些临床特征与手术治疗的口腔鳞状细胞癌（OSCC）患者的5年生存率相关在Taiwan.Patients和方法：378例OSCC患者手术治疗或不化疗和放疗的记录进行了回顾性分析。他们的5年生存率与年龄，性别，肿瘤部位，淋巴结受累，存在远处转移，分期，分化，和危险因素，包括嚼槟榔（BQ），吸烟，饮酒，进行了analyzed.Results：大多数患者是男性（男女比例，5.87：1），平均年龄为57.1 +/- 11.7岁。肿瘤主要发生在颊粘膜（BM）（100/378，26.5%）、牙龈（105/378，27.8%）和舌（103/378，27.2%）。颈部淋巴结转移多发生在口底（>60%），其次是牙龈（45.7%）、颊粘膜（34%）和舌（20.4%），而早期远处转移罕见（5.3%）。有104例（27.5%）1期、96例（25.4%）2期、98例（25.9%）3期和80例（21.2%）4期患者。BM和牙龈的OSCC与BQ使用和吸烟的风险因素相关性最大（舌头最小）。I、II、III和IV期患者的5年生存率分别为75%、65.6%、49%和30%。肿瘤大小、淋巴结转移、远处转移、分期、分化程度和BQ的使用对生存率有显著影响（P <0.05，Kaplan-Meier分析）。BQ的使用也与OSCC患者的发病年龄最小相关。结论：我们的数据表明，早期治疗是提高OSCC患者生存率的关键。定期筛检口腔鳞状细胞癌的高风险人群是台湾的迫切需要。(C)2003年美国口腔颌面外科医师协会。
Purpose: The study goal was to determine which clinical features correlated with 5-year survival in patients surgically treated for oral squamous cell carcinoma (OSCC) in Taiwan.Patients and Methods: The records of 378 OSCC patients surgically treated with or without chemotherapy and radiotherapy were reviewed retrospectively. Their 5-year survival in relation to age, gender, tumor site, lymph node involvement, presence of distant metastasis, staging, differentiation, and risk factors, including betel quid (BQ) chewing, cigarette smoking, and alcohol consumption, was analyzed.Results: The majority of the patients were men (male-to-female ratio, 5.87:1) with the mean age of 57.1 +/- 11.7 years. Tumors occurred mainly at the buccal mucosa (BM) (100 of 378, 26.5%), gingiva (105 of 378, 27.8%), and tongue (103 of 378, 27.2%). Neck nodal metastasis occurred frequently at the floor of the mouth (in >60% of cases), followed by the gingiva (45.7%), buccal mucosa (34%), and tongue (20.4%), whereas early distant metastasis was rare (5.3%). There were 104 (27.5%) stage 1, 96 (25.4%) stage 2, 98 (25.9%) stage 3, and 80 (21.2%) stage 4 patients. OSCC at the BM and gingiva was most (and at the tongue least) associated with risk factors of BQ use and smoking. The 5-year survival was 75%, 65.6%, 49%, and 30% for patients with stage I, II, III, and IV, respectively. The size, nodal involvement, distant metastasis, staging, differentiation, and BQ use significantly affected the survival (P < .05, Kaplan-Meier analysis). BQ use also correlated most significantly with the younger age of occurrence of OSCC patients.Conclusions: our data suggest that early treatment is the key to increasing the survival of OSCC patients. Periodic screening of high-risk populations for OSCC represents an urgent need in Taiwan. (C) 2003 American Association of Oral and Maxillofacial Surgeons.