Blood harmane concentrations and dietary protein consumption in essential tremor
Blood harmane concentrations and dietary protein consumption in essential tremor
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DOI：
10.1212/01.wnl.0000172352.88359.2d
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发表时间：
2005-08-09
期刊：
影响因子：
9.9
通讯作者：
Factor-Litvak, P
中科院分区：
文献类型：
--
作者：
Louis, ED;Zheng, W;Factor-Litvak, P
背景：β-卡波林生物碱(如哈曼)是高度催眠的化学物质。动物蛋白(肉类)是这些生物碱的主要饮食来源。作者先前证明，与对照组相比，特发性震颤(ET)患者的血液中Harmane浓度升高。这种差异是由于患者摄入了更多的动物蛋白，还是由于他们未能代谢Harmane，目前尚不清楚。目的：本研究的目的是确定ET患者和对照组在1)每日动物蛋白摄入量以及2)动物蛋白摄入量与血液中有害物质浓度之间的相关性方面是否存在差异。方法：采用半定量食物频率问卷调查方法收集膳食资料，计算每日卡路里和动物蛋白及其他食物的消耗量。血HARM浓度为对数转换(LogHA)。结果：10 6例患者的平均对数HA高于16 1例对照组(0.6 1+/-0.67vs0.43+/-0.72g(-10)/m L，p=0.035)。患者和对照组摄入了相似数量的动物蛋白(50.2+/-19.6vs49.4+/-19.1g/天，p=0.74)和其他食物类型(动物脂肪、碳水化合物、植物脂肪)，并有相似的热量摄入。在对照组中，LogHA与每日动物蛋白摄入量呈正相关(r=0.24，p=0.003)，而在患者中则无相关性(r=-0.003，p=0.98)。结论：患者和对照组每日动物蛋白摄入量相似，且患者每日动物蛋白摄入量与logHA之间缺乏正常相关性，提示另一个因素(如代谢缺陷)可能是患者血液中HARM浓度增加。
Background: beta-Carboline alkaloids (e. g., harmane) are highly tremorogenic chemicals. Animal protein ( meat) is the major dietary source of these alkaloids. The authors previously demonstrated that blood harmane concentrations were elevated in patients with essential tremor (ET) vs controls. Whether this difference is due to greater animal protein consumption by patients or their failure to metabolize harmane is unknown. Objective: The aim of this study was to determine whether patients with ET and controls differ with regard to 1) daily animal protein consumption and 2) the correlation between animal protein consumption and blood harmane concentration. Methods: Data on current diet were collected with a semiquantitative food frequency questionnaire and daily calories and consumption of animal protein and other food types was calculated. Blood harmane concentrations were log-transformed (logHA). Results: The mean logHA was higher in 106 patients than 161 controls (0.61 +/- 0.67 vs 0.43 +/- 0.72 g(-10)/mL, p = 0.035). Patients and controls consumed similar amounts of animal protein (50.2 +/- 19.6 vs 49.4 +/- 19.1 g/day, p = 0.74) and other food types (animal fat, carbohydrates, vegetable fat) and had similar caloric intakes. In controls, logHA was correlated with daily consumption of animal protein (r = 0.24, p = 0.003); in patients, there was no such correlation (r = -0.003, p = 0.98). Conclusions: The similarity between patients and controls in daily animal protein consumption and the absence of the normal correlation between daily animal protein consumption and logHA in patients suggests that another factor (e. g., a metabolic defect) may be increasing blood harmane concentration in patients.