Involvement of nitric oxide in insulin induced memory improvement
Involvement of nitric oxide in insulin induced memory improvement
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DOI：
10.1016/j.peptides.2008.01.005
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发表时间：
2008-06-01
期刊：
影响因子：
3
通讯作者：
Naghdi, N.
中科院分区：
文献类型：
--
作者：
Choopani, S.;Moosavi, M.;Naghdi, N.
虽然脑被认为是胰岛素不敏感的器官，但最近发现胰岛素对海马等脑区有一些有趣的影响。已知脑内施用胰岛素可以改善学习和记忆。已知胰岛素可以通过eNOS激活来刺激一氧化氮（NO）的合成，并且NO合酶（NOS）抑制剂可以影响学习和记忆，本研究的目的是评估NO是否参与胰岛素诱导的记忆改善。Wistar雄性大鼠CA 1内插管，在Morris水迷宫（MWM）任务的单日测试版本中评估训练后和探测试验前海马内施用N-硝基-L-精氨酸甲酯（L-NAME）（5、10、30 μ g）、胰岛素+ L-NAME +/-L-精氨酸的效果。我们的研究结果表明，L-NAME可以阻止胰岛素诱导的记忆改善。该药物对非空间视觉辨别任务的逃避潜伏期没有影响。因此，内源性一氧化氮似乎在胰岛素引起的空间学习记忆改善中具有作用。(C)2008年爱思唯尔公司版权所有
Although brain was considered as an insulin-insensitive organ, recently it has appeared that insulin has some interesting effects on some brain regions like hippocampus. It has been known that intra-hippocampally administered insulin can improve learning and memory. Knowing that insulin can stimulate nitric oxide (NO) synthesis via eNOS activation and also that NO synthase (NOS) inhibitors can affect learning and memory, the aim of this study was to assess if NO is involved in insulin induced memory improvement. Wistar male rats were intra-CA1 cannulated and the effect of post-training and pre-probe trial intra-hippocampal administration of N-nitro-L-arginine methyl ester (L-NAME) (5, 10, 30 mu g), insulin + L-NAME +/- L-arginine were assessed in a single-day testing version of Morris water maze (MWM) task. Our results show that, L-NAME can prevent insulin induced memory improvement. This drug had no effect on escape latency of a non-spatial visual discrimination task. Therefore, it seems that endogenous nitric oxide has a role in spatial learning and memory improvement caused by insulin. (C) 2008 Elsevier Inc. All rights reserved