DNA METHYLATION AND CPG SUPPRESSION
DNA METHYLATION AND CPG SUPPRESSION
复制标题
DOI：
10.1016/0045-6039(85)90488-9
复制
发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
GERBERHUBER, S
中科院分区：
文献类型：
--
作者：
COOPER, DN;GERBERHUBER, S
脊椎动物基因组中的胞嘧啶甲基化主要发生在二核苷酸CG处。这种二核苷酸在脊椎动物DNA中是缺乏的，这一观察结果迄今为止一直被解释为S-甲基胞嘧啶被动脱氨为胸苷。由于CpG的频率和分布可能被证明是研究DNA甲基化功能的有用的间接手段，因此有趣的是，在编码序列内和周围观察到的“CG抑制”不太明显。现在看来，尽管伴随着明显的突变，但各种不同的机制似乎负责维持这些区域中相对较高的CG水平。
Cytosine methylation in vertebrate genomes occurs predominantly at the dinucleotide CG. This dinucleotide is deficient in vertebrate DNA, an observation which has hitherto been explained by passive deamination of S-methylcytosine to thymidine. Since the frequency and distribution of CpG may prove to be a useful indirect means to study the function of DNA methylation, it is of interest that the observed ''CG suppression'' is less apparent within and around coding sequences. A variety of different mechanisms now appear to be responsible for maintaining a relatively high CG level in these regions despite the apparent attendant disadvantave of mutation.