Tau protein in cerebrospinal fluid: a new diagnostic and prognostic marker in Alzheimer disease?
Tau protein in cerebrospinal fluid: a new diagnostic and prognostic marker in Alzheimer disease?
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脑脊液中的 Tau 蛋白：阿尔茨海默病的新诊断和预后标志物？
DOI：
10.1097/00002093-199809000-00015
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发表时间：
1998
影响因子：
2.1
通讯作者：
U. Senin
中科院分区：
文献类型：
--
作者：
P. Mecocci;A. Cherubini;M. Bregnocchi;F. Chionne;R. Cecchetti;D. Lowenthal;U. Senin
Tau 蛋白是成对螺旋丝的主要蛋白质。它可以在脑脊液 (CSF) 中检测和测量，因此被提议作为阿尔茨海默病 (AD) 的可能体内标志物。为了评估 CSF tau 在 AD 诊断中的有用性，我们通过特定的酶联免疫吸附测定测试在 AD、额叶痴呆 (FLD)、血管性痴呆 (VD) 患者和健康对照中测量了 CSF tau。 AD 患者的 tau 蛋白水平显着高于 FLD、VD 和对照组。晚发性 AD 患者的水平显着高于早发性 AD 患者。在 AD 中，脑脊液 tau 水平与年龄、病程或疾病严重程度无关，而在 FLD 和对照组中发现与年龄相关。在 2 年后重复测量 CSF tau 的 9 名 AD 患者中，尽管认知表现出现恶化，但平均水平与基线没有差异。不同组之间的重叠以及随着时间的推移没有任何改变表明，脑脊液 tau 测量不仅可以确认或分期明显的 AD，还可能有助于揭示该疾病的临床前阶段。
Tau is the main protein of paired helical filaments. It can be detected and measured in cerebrospinal fluid (CSF) and for this reason it has been proposed as a possible in vivo marker of Alzheimer disease (AD). To evaluate the usefulness of CSF tau in the diagnosis of AD we measured it in patients with AD, frontal lobe dementia (FLD), vascular dementia (VD), and in healthy controls by means of a specific enzyme-linked immunosorbent assay test. Individuals with AD had significantly higher tau levels than FLD, VD, and controls. Individuals with late onset AD had significantly higher levels than those with early onset disease. In AD, CSF tau level did not correlate with age, duration, or severity of the disease, whereas a correlation with age was found in FLD and controls. In the nine AD patients in whom CSF tau measurement was repeated after 2 years, mean levels did not differ from baseline, although a worsening of cognitive performances occurred. The overlap among the different groups and the absence of any modification over time suggest that CSF tau measurement, more than in confirming or staging overt AD, might be useful in revealing the disease at its preclinical phase.