Noninvasive and invasive evaluation of pulmonary arterial pressure in highlanders
Noninvasive and invasive evaluation of pulmonary arterial pressure in highlanders
复制标题
高地人肺动脉压的无创和有创评估
DOI：
10.1183/09031936.00137605
复制
发表时间：
2006
影响因子：
24.3
通讯作者：
A. Aldashev
中科院分区：
文献类型：
--
作者：
B. Kojonazarov;B. Imanov;T. A. Amatov;M. Mirrakhimov;R. Naeije;Mark Wilkins;A. Aldashev
The purpose of the present study was to evaluate Doppler echocardiography for the detection of pulmonary hypertension in high-altitude inhabitants. In total, 60 (55 male) patients aged 18–71 yrs were recruited from an ECG screening programme applied to 1,430 inhabitants living at an altitude of 2,500–3,600 m in Kyrgyzstan. Of these, 44 met ECG criteria for right ventricular hypertrophy. All underwent Doppler echocardiography followed by a cardiac catheterisation within 7 days of arrival in Bishkek (Kyrgyzstan; altitude 760 m). Pulmonary flow acceleration time and the maximum velocity of tricuspid regurgitation were measured. Sufficient quality tricuspid regurgitant jets were recovered in only 28% of the patients. Therefore, pulmonary artery pressure was estimated from the pulmonary flow acceleration time, which was recovered in 100% of the patients. It was found that 37 (62%) of the patients had pulmonary hypertension on echocardiography. Pulmonary hypertension was confirmed in 29 patients on catheterisation. Pulmonary hypertension was detected with 70% sensitivity and 88% specificity by echocardiography, as compared to 59% sensitivity and 81 % specificity by ECG. The correlation coefficient between echocardiography and catheterisation studies was r2 = 0.78. It is concluded that a combination of ECG and echocardiography may be useful for screening high-altitude pulmonary hypertension.
