Critical appraisal of the potential use of cannabinoids in cancer management.
Critical appraisal of the potential use of cannabinoids in cancer management.
复制标题
DOI：
10.2147/cmar.s36105
复制
发表时间：
2013-01-01
影响因子：
3.3
通讯作者：
Rosengren, Rhonda J
中科院分区：
文献类型：
--
作者：
Cridge, Belinda J;Rosengren, Rhonda J
大麻素作为潜在的抗癌剂已经引起了极大的兴趣。最初来源于植物大麻，现在有许多内，植物和合成大麻素可用。这篇综述总结了迄今为止围绕这一广泛化合物的作用、抗肿瘤活性和作用机制的关键文献。大麻素主要由激活大麻素受体-CB 1或CB 2的能力来定义。大麻素的作用非常依赖于测试的确切配体，剂量和暴露的持续时间。一些合成或植物衍生的大麻素显示出作为治疗剂的潜力，一系列癌症的证据以及体外和体内的证据正在开始积累。目前已经在广泛的细胞系中进行了研究，包括神经胶质瘤、乳腺、前列腺、内皮、肝脏和肺。这项工作得到了越来越多的体内模型证据的补充。然而，其中许多结果仍然相互矛盾，目前无法通过对作用机制的现有知识解决这一问题。虽然有一个发展中的了解潜在的作用机制，与细胞外信号调节激酶途径出现作为一个关键的信号结合神经酰胺和脂质信号的重要作用，每个途径的相对重要性尚未确定。细胞内自噬途径与细胞凋亡之间的相互作用是最近的发展，讨论。总的来说，关于天然或合成的大麻素作为治疗剂的未来效用，仍然存在大量相互矛盾的证据。
Cannabinoids have been attracting a great deal of interest as potential anticancer agents. Originally derived from the plant Cannabis sativa, there are now a number of endo-, phyto- and synthetic cannabinoids available. This review summarizes the key literature to date around the actions, antitumor activity, and mechanisms of action for this broad range of compounds. Cannabinoids are largely defined by an ability to activate the cannabinoid receptors - CB1 or CB2. The action of the cannabinoids is very dependent on the exact ligand tested, the dose, and the duration of exposure. Some cannabinoids, synthetic or plant-derived, show potential as therapeutic agents, and evidence across a range of cancers and evidence in vitro and in vivo is starting to be accumulated. Studies have now been conducted in a wide range of cell lines, including glioma, breast, prostate, endothelial, liver, and lung. This work is complemented by an increasing body of evidence from in vivo models. However, many of these results remain contradictory, an issue that is not currently able to be resolved through current knowledge of mechanisms of action. While there is a developing understanding of potential mechanisms of action, with the extracellular signal-regulated kinase pathway emerging as a critical signaling juncture in combination with an important role for ceramide and lipid signaling, the relative importance of each pathway is yet to be determined. The interplay between the intracellular pathways of autophagy versus apoptosis is a recent development that is discussed. Overall, there is still a great deal of conflicting evidence around the future utility of the cannabinoids, natural or synthetic, as therapeutic agents.