Comparison of Cardio-Ankle Vascular Index (CAVI) and CAVI0 in Large Healthy and Hypertensive Populations
Comparison of Cardio-Ankle Vascular Index (CAVI) and CAVI0 in Large Healthy and Hypertensive Populations
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DOI：
10.5551/jat.48314
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发表时间：
2019-01-01
影响因子：
4.4
通讯作者：
Takahashi, Koji
中科院分区：
文献类型：
--
作者：
Shirai, Kohji;Suzuki, Kenji;Takahashi, Koji
目的：心踝血管指数（cardio-ankle vascular index， CAVI）表示从主动脉起始点到踝关节处与血压无关的动脉僵硬度。CAVI(0)被提出作为一种变异指标。我们的目的是澄清CAVI和CAVI(0)在大人群中的差异，并探讨差异的原因。方法：选取日本健康人5293例，高血压患者3338例。以年龄、性别、体重指数、收缩压和舒张压（Pd）为变量进行简单和多元回归分析。按性别和年龄进行亚组分析。并比较了参考压力调整前后的CAVI值。结果：健康人群CAVI与Pd呈正相关，CAVI(0)与Pd呈负相关。高血压组男性和女性的CAVI值均高于健康组，但30 ~ 39岁高血压组女性的CAVI(0)值明显低于相应的健康组。健康组和高血压组的CAVI值差异分别为1.09% +/- 1.38%和3.68% +/- 1.66%。结论：CAVI符合预期值，但CAVI(0)在健康人群和高血压人群中表现出难以解释的结果。这种差异是由于CAVI(0)对Pd有很强的依赖性。有或没有参考压力时，CAVI值的差异可以忽略不计。这些结果表明VaSera系统得到的CAVI是合适的，但CAVI(0)不合适。
Aim: The cardio-ankle vascular index (CAVI) represents the blood pressure-independent arterial stiffness from the origin of the aorta to the ankle. CAVI(0) has been proposed as a variant index. We aimed to clarify the difference between CAVI and CAVI(0) among large populations, and to explore reasons of the difference.Methods: The subjects were 5,293 Japanese healthy and 3,338 hypertensive people. Simple and multiple regression analyses were performed using age, sex, body mass index, systolic, and diastolic blood pressure (Pd) as variables. Sub-group analysis was performed by sex and age. The CAVI values with and without adjustment by reference pressure were also compared.Results: CAVI had a positive correlation with Pd, while CAVI(0) had a negative correlation with Pd in the healthy population. The CAVI values of the hypertensive group were higher than those of healthy group in both men and women, but the CAVI(0) values in women of the hypertensive group in the 30-39 age group was significantly lower than that of the corresponding healthy group. Differences of CAVI values with or without modification using the reference pressure were 1.09% +/- 1.38% for the healthy group and 3.68% +/- 1.66% for the hypertensive group.Conclusion: CAVI showed the expected values, but CAVI(0) showed inexplicable results in the healthy and hypertensive populations. The differences were due to the strong dependency of CAVI(0) on Pd. Differences of CAVI values with or without reference pressure were negligible. These results indicate that CAVI obtained by the VaSera system is appropriate, but CAVI(0) is not.