Population-based study for human papillomavirus (HPV) infection in young women in Japan: A multicenter study by the Japanese human papillomavirus disease education research survey group (J-HERS)
Population-based study for human papillomavirus (HPV) infection in young women in Japan: A multicenter study by the Japanese human papillomavirus disease education research survey group (J-HERS)
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DOI：
10.1002/jmv.24323
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发表时间：
2016-02-01
影响因子：
12.7
通讯作者：
Irie, Takuya
中科院分区：
文献类型：
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作者：
Sasagawa, Toshiyuki;Maehama, Toshiyuki;Irie, Takuya
一项多中心研究对6,628名年龄在16至50岁的符合条件的日本女性进行了宫颈异常和HPV感染的检查，采用液体细胞学检查和一种新型HPV检测，使用PCR-SSOP-Luminex（(R)）方法鉴定了31种HPV基因型。在3047名正常受试者中，所有HPV类型的总体患病率为25%，而常见的13种高危（common - 13hr）类型（HPV- 16,18）的患病率为25%。31、33、35、39、45、51、52、56、58、59、68)为17%，明确高危型（define - hr） （HPV-16、18）为17%。31、33、35、45、52、58)为12%。对于define - hr， HPV-52、16和58是最常见的，HPV-31相对常见，HPV-18不常见，而HPV-33、35和45是罕见的。在高度鳞状上皮内病变（HSIL）或更严重的患者中，7种确定型hr（不包括HPV-45）和7种可能型hr (HPV-39、51、56、66、68、70和82)HPV类型被确定为单一类型感染。在89%的HSIL患者中检测到Common-13HR类型，而在95%的HSIL患者中检测到Definite-HR或Possible-HR类型。在日本，这1420种HPV类型似乎与HSIL有关或更严重。在大约一半的HPV阳性受试者中发现了多型HPV感染的患病率，在正常人群和异常细胞学组中，多型HPV感染的患病率随着年龄的增长而显著下降，而在异常细胞学组中，单型HPV感染的患病率随着年龄的增长而增加。大多数HPV感染在几年内被清除，而某些HR-HPV型持续诱导HSIL。(c) 2015 Wiley期刊公司
A multi-center study was conducted to examine 6,628 eligible Japanese women aged from 16 to 50 years for uterine cervical abnormality and HPV infection with a liquid based-cytology test and a novel HPV test using the PCR-SSOP-Luminex((R)) method identifying 31 HPV genotypes. In 3,047 normal subjects, the overall prevalence across all HPV types was 25%, while that of the common 13 high-risk (Common-13HR) types (HPV-16, 18. 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68) was 17%, and that of the definite high-risk (Definite-HR) types (HPV-16, 18. 31, 33, 35, 45, 52, and 58) was 12%. For Definite-HR, HPV-52, 16, and 58 were the most common, HPV-31 was relatively common, and HPV-18 was less common, while HPV-33, 35, and 45 were rare. Seven Definite-HR excluding HPV-45 and seven Possible-HR (HPV-39, 51, 56, 66, 68, 70, and 82) HPV types were identified as a single type infection in patients with high-grade squamous intraepithelial lesion (HSIL) or worse. The Common-13HR types were detected in 89% of subjects with HSIL, whereas either Definite-HR or Possible-HR types were detected in 95% of HSIL. These 1420 HPV types appear to be involved with HSIL or worse in Japan. The prevalences of multiple-type HPV infections were identified in roughly half of HPV-positive subjects, and decreased significantly with age in normal population and abnormal cytology groups, although the prevalences of single-type infections increased with age in the latter group. Most HPV infections are cleared for some years, while a certain HR-HPV type persists to induce HSIL. (c) 2015 Wiley Periodicals, Inc.