Association of ambient air pollution with age-related macular degeneration and retinal thickness in UK Biobank
Association of ambient air pollution with age-related macular degeneration and retinal thickness in UK Biobank
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DOI：
10.1136/bjophthalmol-2020-316218
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发表时间：
2021-01-22
影响因子：
4.1
通讯作者：
Patel, Praveen J.
中科院分区：
文献类型：
--
作者：
Chua, Sharon Y. L.;Warwick, Alasdair;Patel, Praveen J.
目的研究空气污染与自我报告的年龄相关性黄斑变性（AMD）和视网膜亚层厚度的体内测量的相关性。方法我们纳入了115 954名年龄在40-69岁的英国生物银行参与者。环境空气污染措施包括颗粒物、二氧化氮和氮氧化物。排除了自我报告的眼部疾病、高屈光不正（< -6 or >+6屈光度）和光谱域光学相干断层扫描（SD-OCT）图像差的参与者。自我报告的AMD被用来识别显性疾病。采用SD-OCT成像获得的光感受器亚层厚度和视网膜色素上皮（RPE）层厚度作为52602名参与者的AMD结构生物标志物。我们研究了环境空气污染与自我报告的AMD以及感光细胞亚层和RPE层厚度的关系。结果在调整协变量后，暴露于空气动力学直径较高的细颗粒物的人，
Aim To examine the associations of air pollution with both self-reported age-related macular degeneration (AMD), and in vivo measures of retinal sublayer thicknesses. Methods We included 115 954 UK Biobank participants aged 40-69 years old in this cross-sectional study. Ambient air pollution measures included particulate matter, nitrogen dioxide (NO2) and nitrogen oxides (NOx). Participants with self-reported ocular conditions, high refractive error (< -6 or > +6 diopters) and poor spectral-domain optical coherence tomography (SD-OCT) image were excluded. Self-reported AMD was used to identify overt disease. SD-OCT imaging derived photoreceptor sublayer thickness and retinal pigment epithelium (RPE) layer thickness were used as structural biomarkers of AMD for 52 602 participants. We examined the associations of ambient air pollution with self-reported AMD and both photoreceptor sublayers and RPE layer thicknesses. Results After adjusting for covariates, people who were exposed to higher fine ambient particulate matter with an aerodynamic diameter