The Applicability of Lean and Six Sigma Techniques to Clinical and Translational Research
The Applicability of Lean and Six Sigma Techniques to Clinical and Translational Research
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DOI：
10.2310/jim.0b013e3181b91b3a
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发表时间：
2009-10-01
影响因子：
2.6
通讯作者：
Dembe, Allard E.
中科院分区：
文献类型：
--
作者：
Schweikhart, Sharon A.;Dembe, Allard E.
背景：精益和六西格玛是生产行业常用的企业管理策略，用于提高流程效率和质量。在过去十年中，这些过程改进技术越来越多地应用于制造业以外的领域，例如医疗保健和软件开发。本文关注的是精益和六西格玛在改善临床和转化研究过程中的潜在用途。提高质量，避免延误和错误，加快时间来实施生物医学发现的主要目标是美国国立卫生研究院（NIH）的医学研究路线图和NIH的临床和转化科学奖program.Methods：本文介绍了一个描述的主要原则，实践和方法，在精益和六西格玛。现有的文献涉及应用精益和六西格玛医疗保健，实验室科学，临床和转化研究进行审查。关于使用这些技术在不同阶段的转化research.Results的具体问题：正在计划在当前的临床和转化科学奖网站的精益和六西格玛应用程序的例子提供，这可能会被复制到其他地方。我们描述了不同的过程改进方法是如何最好地适应特定的translational research phases.Conclusions：精益和六西格玛过程改进方法非常适合帮助实现NIH的目标，使临床和转化研究更有效，更具成本效益，提高研究质量，并促进成功地采用生物医学研究成果付诸实践。
Background: Lean and Six Sigma are business management strategies commonly used in production industries to improve process efficiency and quality. During the past decade, these process improvement techniques increasingly have been applied outside the manufacturing sector, for example, in health care and in software development. This article concerns the potential use of Lean and Six Sigma in improving the processes involved in clinical and translational research. Improving quality, avoiding delays and errors, and speeding up the time to implementation of biomedical discoveries are prime objectives of the National Institutes of Health (NIH) Roadmap for Medical Research and the NIH's Clinical and Translational Science Award program.Methods: This article presents a description of the main principles, practices, and methods used in Lean and Six Sigma. Available literature involving applications of Lean and Six Sigma to health care, laboratory science, and clinical and translational research is reviewed. Specific issues concerning the use of these techniques in different phases of translational research are identified.Results: Examples of Lean and Six Sigma applications that are being planned at a current Clinical and Translational Science Award site arc provided, which could potentially be replicated elsewhere. We describe how different process improvement approaches are best adapted for particular translational research phases.Conclusions: Lean and Six Sigma process improvement methods are well suited to help achieve NIH's goal of making clinical and translational research more efficient and cost-effective, enhancing the quality of the research, and facilitating the successful adoption of biomedical research findings into practice.