A retrospective study on the microbiology in patients with oral complaints and oral mucosal lesions
A retrospective study on the microbiology in patients with oral complaints and oral mucosal lesions
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DOI：
10.1111/j.1601-0825.2009.01520.x
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发表时间：
2009-05-01
期刊：
影响因子：
3.8
通讯作者：
Carlen, A.
中科院分区：
文献类型：
--
作者：
Dahlen, G.;Blomquist, S.;Carlen, A.
本研究对297例口腔黏膜病患者的口腔黏膜标本进行了微生物学分析，并对其中的金黄色葡萄球菌、肠球菌、需氧革兰氏阴性杆菌（AGNB）和酵母菌等条件微生物进行了半定量培养。对297例患者进行了药敏试验，平均年龄56.8 ± 20.7岁。在110名已知疾病的患者中，48名全身免疫功能低下，35名全身疾病，27名仅局部口腔不适。中等生长或以上的机会在所有三组中普遍存在，最常见于免疫功能低下的患者（66.7%）。念珠菌是最常见的机会主义者（68.8%），但其水平较低，与细菌机会主义者的组合很常见（39.6%）。所有的细菌机会测试是抗生素多重耐药。23例随访标本中有7例经环丙沙星反复治疗后仍有大量细菌和真菌感染，其中以免疫功能低下者最常见，局部口腔感染者也常见。需要对不同的治疗策略进行系统评价。
The aim of this study was to microbiologically analyze oral mucosal samples collected during 2 years from patients with oral mucosal complaints.Mucosal scraping samples were taken from 297 patients and semiquantified by culture for detection of opportunistic microorganisms e.g. Staphylococcus aureus, enterococci, aerobic Gram-negative bacilli (AGNB) and yeasts. Antibiotic susceptibility test was performed.Altogether 297 patients were sampled (mean age 56.8 +/- 20.7). Among the 110 patients with known medical condition, 48 were systemically immunocompromised, 35 had systemic diseases, and 27 had only local oral complaints. Opportunists in moderate growth or more were present commonly in all three groups and most frequent in the immunocompromised patients (66.7%). Candida species were the most frequent opportunist (68.8%), however, their level was low and combinations with bacterial opportunists were common (39.6%). All bacterial opportunists tested were antibiotic multiresistant. Follow-up samples were collected in 23 cases out of which seven showed still presence of opportunists in heavy growth despite repeated treatment with ciprofloxacin.This study showed a frequent presence of bacterial and fungal opportunists in patients with oral mucosal complaints, which were most common in immunocompromised individuals, however, also frequent in patients with local oral complaints only. Systematic evaluation of different treatment strategies is needed.