Decrease of human serum fucosyltransferase as an indicator of successful tumor therapy.
Decrease of human serum fucosyltransferase as an indicator of successful tumor therapy.
复制标题
人血清岩藻糖基转移酶的降低作为肿瘤治疗成功的指标。
作者：
C. Bauer;W. Reutter;K. P. Erhart;E. Köttgen;W. Gerok
结肠癌手术切除导致[14C]病灶在人血清中与其内源性受体结合的率降低；在14天内达到正常的注册率。当使用地西罗或地西罗去乳蛋白作为外源性受体时，alpha2-和alpha3-聚焦转移酶也有类似的时间过程。转移酶活性与乳腺癌患者的治疗反应之间也存在相关性。这些结果表明，focusyltransferase活性的测定可以促进肿瘤的诊断，以及手术、化疗或放疗的成功。
Surgical removal of colon carcinomas leads to a decrease in the rate of incorporation of [14C]fucose into its endogenous acceptor in human serum; normal incorporation rates are attained within 14 days. A similar time course has been determined for alpha2- and alpha3-fucosyltransferase when either desialo- or desialodegalactofetuin are employed as exogenous acceptors. A correlation has also been seen between transferase activity and the therapeutic response of patients with breast cancer. These results indicate that the determination of fucosyltransferase activity can facilitate the diagnosis of neoplasia, and the success of surgery, chemotherapy, or radiation.