Improved diagnosis of pleural tuberculosis using the microscopic- observation drug-susceptibility technique.

Improved diagnosis of pleural tuberculosis using the microscopic- observation drug-susceptibility technique.
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DOI:
10.1086/527447
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发表时间:
2008-03-15
期刊:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子:
--
通讯作者:
Evans CA
Evans CA
中科院分区:
其他
文献类型:
--
作者:
Tovar M;Siedner MJ;Gilman RH;Santillan C;Caviedes L;Valencia T;Jave O;Escombe AR;Moore DA;Evans CA

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胸膜结核的检测既不敏感又昂贵。我们比较了非专利镜检药敏(MODS)培养和L-延森培养在胸膜标本评估中的作用。与L-詹森培养相比,MODS培养可显著提高诊断敏感性和缩短诊断时间(活检标本培养的敏感性为81%对51%;诊断时间为11d对24d;P<.001)。MODS技术价格低廉,可以进行药敏试验,是一种相当先进的胸膜结核诊断方法。
Tests for pleural tuberculosis are insensitive and expensive. We compared nonproprietary microscopic-observation drug-susceptibility (MODS) culture with Löwenstein-Jensen culture for evaluation of pleural specimens. MODS culture was associated with greatly increased diagnostic sensitivity and shorter time to diagnosis, compared with Löwenstein-Jensen culture (sensitivity of culture of biopsy specimens, 81% vs. 51%; time to diagnosis, 11 days vs. 24 days; P < .001). The MODS technique is inexpensive, allows drug-susceptibility testing, and is a considerably improved diagnostic method for pleural tuberculosis.
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