A computer reconstruction of the entire coronary arterial tree based on detailed morphometric data
A computer reconstruction of the entire coronary arterial tree based on detailed morphometric data
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DOI：
10.1007/s10439-005-5758-z
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发表时间：
2005-11-01
影响因子：
3.8
通讯作者：
Kassab, GS
中科院分区：
文献类型：
--
作者：
Mittal, N;Zhou, Y;Kassab, GS
血流的严格分析必须基于分支模式和血管几何的完整的血管回路感兴趣。由于血管的巨大，在实验上很难重建任何器官的整个血管回路。本研究的目的是开发一种从部分测量重建全冠状动脉血管树的新方法。我们的方法包括使用树中被测量部分的数据来推断缺失部分的数据。具体而言，采用两步方法重建整个冠状动脉树直至毛细血管水平。根据铸型资料重建bb0 ~ 40 μ m的血管，根据组织学资料重建< 40 μ m的血管。通过“切割”和“粘贴”测量到缺失血管的数据，一次重建一个分支的铸型数据，一次重建一个子树的组织学数据。重建算法生成了一个完整的动脉树，直到第一个毛细血管分叉，分别为右冠状动脉（RCA）、左前降支（LAD）和左旋支（LCx）树，分别有1.9万个、204万个和115万个血管段。节点到节点的连通性以及每个血管段的直径和长度被确定。一旦整个采油树重建完成，我们将根据直径定义的Strahler系统自动分配订单号给采油树中的每个管道段。因此，确定了每个订单号的直径、长度、容器数量、单元段比、连通性和纵向矩阵。本模型为今后冠状动脉循环血流分析奠定了形态学基础。
A rigorous analysis of blood flow must be based on the branching pattern and vascular geometry of the full vascular circuit of interest. It is experimentally difficult to reconstruct the entire vascular circuit of any organ because of the enormity of the vessels. The objective of the present study was to develop a novel method for the reconstruction of the full coronary vascular tree from partial measurements. Our method includes the use of data on those parts of the tree that are measured to extrapolate the data on those parts that are missing. Specifically, a two-step approach was employed in the reconstruction of the entire coronary arterial tree down to the capillary level. Vessels > 40 mu m were reconstructed from cast data while vessels < 40 mu m were reconstructed from histological data. The cast data were reconstructed one-bifurcation at a time while histological data were reconstructed one-sub-tree at a time by "cutting" and "pasting" of data from measured to missing vessels. The reconstruction algorithm yielded a full arterial tree down to the first capillary bifurcation with 1.9, 2.04 and 1.15 million vessel segments for the right coronary artery (RCA), left anterior descending (LAD) and left circumflex (LCx) trees, respectively. The node-to-node connectivity along with the diameter and length of every vessel segment was determined. Once the full tree was reconstructed, we automated the assignment of order numbers, according to the diameter-defined Strahler system, to every vessel segment in the tree. Consequently, the diameters, lengths, number of vessels, segments-per-element ratio, connectivity and longitudinal matrices were determined for every order number. The present model establishes a morphological foundation for future analysis of blood flow in the coronary circulation.