Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy
Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy
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DOI：
10.1007/s00417-017-3774-y
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发表时间：
2017-11-01
影响因子：
2.7
通讯作者：
Ciardella, Antonio
中科院分区：
文献类型：
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作者：
Balducci, Nicole;Morara, Mariachiara;Ciardella, Antonio
我们研究的目的是使用光学相干断层扫描血管造影 (OCT-A) 描述急性非动脉炎性或动脉炎性前部缺血性视神经病变 (NA-AION 和 A-AION) 的特征，并将其与荧光素血管造影 (FA) 和吲哚青绿血管造影 (ICGA) 进行比较。在这项回顾性、观察性病例对照研究中，四名 NA-AION 患者和一名 A-AION 患者在发病后 2 周内接受 FA、ICGA 和 OCT-A 检查。分析了图像的特征。比较 NA-AION 和对照之间的视神经乳头 (ONH) 和径向乳头周围毛细血管 (RPC) 血管密度 (VD)。在 4 例 NA-AION 病例中的 2 例和 A-AION 患者中，OCT-A 清楚地识别了视神经乳头水平的缺血区域的边界，这与 FA 检测到的视盘充盈缺损相当。在另外两个 NA-AION 病例中，FA 可以看到椎间盘普遍渗漏，但 OCT-A 仍然显示扇形乳头周围毛细血管网络减少。与对照组相比，NA-AION 患者的 ONH 和 RPC VD 均减少。OCT-A 能够识别 NA-AION 和 A-AION 引起的急性视盘水肿病例中的微血管缺陷和 VD 减少。 OCT-A 提供有关视神经乳头缺血情况的附加信息。
The purpose of our study was to describe the feature of acute non-arteritic or arteritic anterior ischemic optic neuropathy (NA-AION and A-AION) using optical coherence tomography angiography (OCT-A) and to compare it with fluorescein angiography (FA) and indocyanine green angiography (ICGA).In this retrospective, observational case-control study four NA-AION patients and one A-AION patient were examined by FA, ICGA and OCT-A within 2 weeks from disease presentation. The characteristics of the images were analyzed. Optic nerve head (ONH) and radial peripapillary capillaries (RPC) vessel densities (VDs) were compared between NA-AION and controls.In two of four NA-AION cases and in the A-AION patient, OCT-A clearly identified the boundary of the ischemic area at the level of the optic nerve head, which was comparable to optic disc filling defects detected by FA. In the other two NA-AION cases, a generalized leakage from the disc was visible with FA, yet OCT-A still demonstrated sectorial peripapillary capillary network reduction. Both ONH and RPC VDs were reduced in NA-AION patients, when compared to controls.OCT-A was able to identify microvascular defects and VD reduction in cases of acute optic disc edema due to NA-AION and A-AION. OCT-A provides additional information in ischemic conditions of the optic nerve head.